Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients

T Mark Doherty; Abebech Demissie; Joseph Olobo; Dawit Wolday; Sven Britton; Tewodros Eguale; Pernille Ravn; Peter Andersen

Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients

T Mark Doherty, Abebech Demissie, Joseph Olobo, Dawit Wolday, Sven Britton, Tewodros Eguale, Pernille Ravn, Peter Andersen

Research output: Contribution to journal › Journal article › Research › peer-review

226 Citations (Scopus)

Abstract

Diagnosis of latent Mycobacterium tuberculosis infection is considered essential for tuberculosis control but is hampered by the lack of specific reagents. We report that strong recognition of tuberculosis complex-specific antigen ESAT-6 by healthy household contacts of tuberculosis patients correlates with the subsequent development of active tuberculosis during a 2-year follow-up period.

Original language	English
Journal	Journal of Clinical Microbiology
Volume	40
Issue number	2
Pages (from-to)	704-6
Number of pages	2
ISSN	0095-1137
Publication status	Published - 2002

Cite this

Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients. / Doherty, T Mark; Demissie, Abebech; Olobo, Joseph; Wolday, Dawit; Britton, Sven; Eguale, Tewodros; Ravn, Pernille; Andersen, Peter.

In: Journal of Clinical Microbiology, Vol. 40, No. 2, 2002, p. 704-6.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Diagnosis of latent Mycobacterium tuberculosis infection is considered essential for tuberculosis control but is hampered by the lack of specific reagents. We report that strong recognition of tuberculosis complex-specific antigen ESAT-6 by healthy household contacts of tuberculosis patients correlates with the subsequent development of active tuberculosis during a 2-year follow-up period.",

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AU - Doherty, T Mark

AU - Demissie, Abebech

AU - Olobo, Joseph

AU - Wolday, Dawit

AU - Britton, Sven

AU - Eguale, Tewodros

AU - Ravn, Pernille

AU - Andersen, Peter

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AB - Diagnosis of latent Mycobacterium tuberculosis infection is considered essential for tuberculosis control but is hampered by the lack of specific reagents. We report that strong recognition of tuberculosis complex-specific antigen ESAT-6 by healthy household contacts of tuberculosis patients correlates with the subsequent development of active tuberculosis during a 2-year follow-up period.

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JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

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