Immune stimulating complexes (ISCOMs) and Quil-A containing particulate formulations as vaccine delivery systems

S. Hook; T. Rades

doi:10.1007/978-1-4614-5070-2_12

Immune stimulating complexes (ISCOMs) and Quil-A containing particulate formulations as vaccine delivery systems

S. Hook^*, T. Rades

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

5 Citations (Scopus)

Abstract

Immune stimulating complexes (ISCOMs) belong to the group of particulate vaccine delivery systems. These particles have received considerable attention in the field of vaccine delivery systems, especially for subunit vaccines. ISCOMs have a spherical, open and cage-like structure and a particle size of around 40nm. They contain an adjuvant (Quil A or QS 21) and an antigen incorporated into or associated with their colloidal structure, making ISCOMs particulate antigen delivery systems which allow co-delivery of antigen and adjuvant. In this chapter we initially describe the components, microstructures and preparation methods of ISCOMs followed by their mechanism of immune stimulation and their use as vaccines.

Original language	English
Title of host publication	Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines
Number of pages	29
Publisher	Springer New York
Publication date	1 Jan 2013
Pages	233-261
ISBN (Print)	9781461450696
ISBN (Electronic)	9781461450702
DOIs	https://doi.org/10.1007/978-1-4614-5070-2_12
Publication status	Published - 1 Jan 2013

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media New York 2013. All rights reserved.

Access to Document

10.1007/978-1-4614-5070-2_12

Cite this

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