Impact of cardiovascular risk factors on chronic abdominal pain after laparoscopic gastric bypass

Johanne Gormsen; Jakob Burcharth; Frederik Helgstrand

Impact of cardiovascular risk factors on chronic abdominal pain after laparoscopic gastric bypass

Johanne Gormsen, Jakob Burcharth, Frederik Helgstrand

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

13 Downloads (Pure)

Abstract

INTRODUCTION: Patients with chronic pain after laparoscopic Roux-en-Y gastric bypass (LRYGB) surgery frequently report intense postprandial abdominal pain. Reduced blood supply due to atherosclerosis was hypothesised to be a contributing cause.

METHODS: This was a retrospective, single-centre cohort study including all patients with LRYGB surgery from 2010 through 2015. Data from multiple registries, medical records and a questionnaire were used. The risk of chronic abdominal pain was analysed using multivariate logistic regression.

RESULTS: We included 787 patients. Among these, 177 (23%) patients were defined as having chronic abdominal pain. The median follow-up was 63 months. When investigating the impact of risk factors for atherosclerosis including dyslipidaemia, Type 2 diabetes, hypertension, smoking and cardiovascular co-morbidities, the "atherosclerosis composite score" was a significant risk factor (odds ratio = 1.22, 95% confidence interval: 1.02-1.45). In a multivariate model specifically investigating dyslipidaemia, the association with chronic abdominal pain was non-significant.

CONCLUSIONS: In this exploratory study, development of chronic abdominal pain was significantly associated with risk factors for atherosclerosis, but the specific association with dyslipidaemia was non-significant.

FUNDING: The study was supported by the Danish Medical Association's Research Foundation and the Edgar Schnohr Foundation.

TRIAL REGISTRATION: The study was approved by the Danish Data Protection Agency (No. REG-063-2017).

Original language	English
Article number	A05200330
Journal	Danish Medical Journal
Volume	67
Issue number	11
ISSN	1603-9629
Publication status	Published - 29 Oct 2020

Bibliographical note

Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

Keywords

Abdominal Pain/epidemiology
Cardiovascular Diseases/epidemiology
Cohort Studies
Diabetes Mellitus, Type 2/surgery
Gastric Bypass/adverse effects
Heart Disease Risk Factors
Humans
Laparoscopy
Obesity, Morbid/surgery
Retrospective Studies
Risk Factors
Treatment Outcome

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Impact of cardiovascular risk factors on chronic abdominal pain after laparoscopic gastric bypassFinal published version, 507 KBLicence: CC BY-NC

https://ugeskriftet.dk/dmj/impact-cardiovascular-risk-factors-chronic-abdominal-pain-after-laparoscopic-gastric-bypassLicence: CC BY-NC

Cite this

@article{207f98134f274950bc27f40fcb5249da,

title = "Impact of cardiovascular risk factors on chronic abdominal pain after laparoscopic gastric bypass",

abstract = "INTRODUCTION: Patients with chronic pain after laparoscopic Roux-en-Y gastric bypass (LRYGB) surgery frequently report intense postprandial abdominal pain. Reduced blood supply due to atherosclerosis was hypothesised to be a contributing cause.METHODS: This was a retrospective, single-centre cohort study including all patients with LRYGB surgery from 2010 through 2015. Data from multiple registries, medical records and a questionnaire were used. The risk of chronic abdominal pain was analysed using multivariate logistic regression.RESULTS: We included 787 patients. Among these, 177 (23%) patients were defined as having chronic abdominal pain. The median follow-up was 63 months. When investigating the impact of risk factors for atherosclerosis including dyslipidaemia, Type 2 diabetes, hypertension, smoking and cardiovascular co-morbidities, the {"}atherosclerosis composite score{"} was a significant risk factor (odds ratio = 1.22, 95% confidence interval: 1.02-1.45). In a multivariate model specifically investigating dyslipidaemia, the association with chronic abdominal pain was non-significant.CONCLUSIONS: In this exploratory study, development of chronic abdominal pain was significantly associated with risk factors for atherosclerosis, but the specific association with dyslipidaemia was non-significant.FUNDING: The study was supported by the Danish Medical Association's Research Foundation and the Edgar Schnohr Foundation.TRIAL REGISTRATION: The study was approved by the Danish Data Protection Agency (No. REG-063-2017).",

keywords = "Abdominal Pain/epidemiology, Cardiovascular Diseases/epidemiology, Cohort Studies, Diabetes Mellitus, Type 2/surgery, Gastric Bypass/adverse effects, Heart Disease Risk Factors, Humans, Laparoscopy, Obesity, Morbid/surgery, Retrospective Studies, Risk Factors, Treatment Outcome",

author = "Johanne Gormsen and Jakob Burcharth and Frederik Helgstrand",

note = "Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.",

year = "2020",

month = oct,

day = "29",

language = "English",

volume = "67",

journal = "Danish Medical Journal",

issn = "2245-1919",

publisher = "Almindelige Danske Laegeforening",

number = "11",

}

TY - JOUR

T1 - Impact of cardiovascular risk factors on chronic abdominal pain after laparoscopic gastric bypass

AU - Gormsen, Johanne

AU - Burcharth, Jakob

AU - Helgstrand, Frederik

N1 - Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

PY - 2020/10/29

Y1 - 2020/10/29

N2 - INTRODUCTION: Patients with chronic pain after laparoscopic Roux-en-Y gastric bypass (LRYGB) surgery frequently report intense postprandial abdominal pain. Reduced blood supply due to atherosclerosis was hypothesised to be a contributing cause.METHODS: This was a retrospective, single-centre cohort study including all patients with LRYGB surgery from 2010 through 2015. Data from multiple registries, medical records and a questionnaire were used. The risk of chronic abdominal pain was analysed using multivariate logistic regression.RESULTS: We included 787 patients. Among these, 177 (23%) patients were defined as having chronic abdominal pain. The median follow-up was 63 months. When investigating the impact of risk factors for atherosclerosis including dyslipidaemia, Type 2 diabetes, hypertension, smoking and cardiovascular co-morbidities, the "atherosclerosis composite score" was a significant risk factor (odds ratio = 1.22, 95% confidence interval: 1.02-1.45). In a multivariate model specifically investigating dyslipidaemia, the association with chronic abdominal pain was non-significant.CONCLUSIONS: In this exploratory study, development of chronic abdominal pain was significantly associated with risk factors for atherosclerosis, but the specific association with dyslipidaemia was non-significant.FUNDING: The study was supported by the Danish Medical Association's Research Foundation and the Edgar Schnohr Foundation.TRIAL REGISTRATION: The study was approved by the Danish Data Protection Agency (No. REG-063-2017).

AB - INTRODUCTION: Patients with chronic pain after laparoscopic Roux-en-Y gastric bypass (LRYGB) surgery frequently report intense postprandial abdominal pain. Reduced blood supply due to atherosclerosis was hypothesised to be a contributing cause.METHODS: This was a retrospective, single-centre cohort study including all patients with LRYGB surgery from 2010 through 2015. Data from multiple registries, medical records and a questionnaire were used. The risk of chronic abdominal pain was analysed using multivariate logistic regression.RESULTS: We included 787 patients. Among these, 177 (23%) patients were defined as having chronic abdominal pain. The median follow-up was 63 months. When investigating the impact of risk factors for atherosclerosis including dyslipidaemia, Type 2 diabetes, hypertension, smoking and cardiovascular co-morbidities, the "atherosclerosis composite score" was a significant risk factor (odds ratio = 1.22, 95% confidence interval: 1.02-1.45). In a multivariate model specifically investigating dyslipidaemia, the association with chronic abdominal pain was non-significant.CONCLUSIONS: In this exploratory study, development of chronic abdominal pain was significantly associated with risk factors for atherosclerosis, but the specific association with dyslipidaemia was non-significant.FUNDING: The study was supported by the Danish Medical Association's Research Foundation and the Edgar Schnohr Foundation.TRIAL REGISTRATION: The study was approved by the Danish Data Protection Agency (No. REG-063-2017).

KW - Abdominal Pain/epidemiology

KW - Cardiovascular Diseases/epidemiology

KW - Cohort Studies

KW - Diabetes Mellitus, Type 2/surgery

KW - Gastric Bypass/adverse effects

KW - Heart Disease Risk Factors

KW - Humans

KW - Laparoscopy

KW - Obesity, Morbid/surgery

KW - Retrospective Studies

KW - Risk Factors

KW - Treatment Outcome

M3 - Journal article

C2 - 33215605

VL - 67

JO - Danish Medical Journal

JF - Danish Medical Journal

SN - 2245-1919

IS - 11

M1 - A05200330

ER -