Impact of exogenous hyperglucagonemia on postprandial concentrations of gastric inhibitory polypeptide and glucagon-like peptide-1 in humans

Juris J Meier; Peter R Ritter; Alexandra Jacob; Bjoern A Menge; Carolyn F Deacon; Wolfgang E Schmidt; Michael A Nauck; Jens J Holst

doi:10.1210/jc.2010-0550

Impact of exogenous hyperglucagonemia on postprandial concentrations of gastric inhibitory polypeptide and glucagon-like peptide-1 in humans

Juris J Meier, Peter R Ritter, Alexandra Jacob, Bjoern A Menge, Carolyn F Deacon, Wolfgang E Schmidt, Michael A Nauck, Jens J Holst

Endocrinology and Metabolism

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Abstract

Postprandial secretion of glucagon-like peptide 1 (GLP-1) has been found diminished in some patients with type 2 diabetes mellitus (T2DM) and high glucagon concentrations. We examined the effects of exogenous glucagon on the release of incretin hormones.

Original language	English
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	95
Issue number	8
Pages (from-to)	4061-5
Number of pages	5
ISSN	0021-972X
DOIs	https://doi.org/10.1210/jc.2010-0550
Publication status	Published - 1 Aug 2010

Keywords

Aged
Analysis of Variance
Blood Glucose
C-Peptide
Diabetes Mellitus, Type 2
Female
Gastric Inhibitory Polypeptide
Glucagon
Glucagon-Like Peptide 1
Humans
Incretins
Insulin
Male
Middle Aged
Postprandial Period

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10.1210/jc.2010-0550

Cite this

Impact of exogenous hyperglucagonemia on postprandial concentrations of gastric inhibitory polypeptide and glucagon-like peptide-1 in humans. / Meier, Juris J; Ritter, Peter R; Jacob, Alexandra; Menge, Bjoern A; Deacon, Carolyn F; Schmidt, Wolfgang E; Nauck, Michael A; Holst, Jens J.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 95, No. 8, 01.08.2010, p. 4061-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Meier, Juris J ; Ritter, Peter R ; Jacob, Alexandra ; Menge, Bjoern A ; Deacon, Carolyn F ; Schmidt, Wolfgang E ; Nauck, Michael A ; Holst, Jens J. / Impact of exogenous hyperglucagonemia on postprandial concentrations of gastric inhibitory polypeptide and glucagon-like peptide-1 in humans. In: Journal of Clinical Endocrinology and Metabolism. 2010 ; Vol. 95, No. 8. pp. 4061-5.

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abstract = "Postprandial secretion of glucagon-like peptide 1 (GLP-1) has been found diminished in some patients with type 2 diabetes mellitus (T2DM) and high glucagon concentrations. We examined the effects of exogenous glucagon on the release of incretin hormones.",

keywords = "Aged, Analysis of Variance, Blood Glucose, C-Peptide, Diabetes Mellitus, Type 2, Female, Gastric Inhibitory Polypeptide, Glucagon, Glucagon-Like Peptide 1, Humans, Incretins, Insulin, Male, Middle Aged, Postprandial Period",

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AU - Menge, Bjoern A

AU - Deacon, Carolyn F

AU - Schmidt, Wolfgang E

AU - Nauck, Michael A

AU - Holst, Jens J

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KW - Diabetes Mellitus, Type 2

KW - Female

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KW - Postprandial Period

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