Impact of surgery and chemotherapy timing on outcomes in older versus younger epithelial ovarian cancer patients: A nationwide Danish cohort study

Anne Weng Ekmann-Gade*, Tine Henrichsen Schnack, Lene Seibæk, Mette Calundann Noer, Claus Høgdall

*Corresponding author for this work

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Abstract

Introduction: To explore differences in surgical complexity, chemotherapy administration, and treatment delays between younger and older Danish patients with epithelial ovarian cancer (EOC). Materials and Methods: We included a nationwide cohort diagnosed with EOC from 2013 to 2018. We described surgical complexity and outcomes, the extent of chemotherapy and treatment delays stratified by age (<70 and ≥ 70 years), and surgical modality (primary, interval, or no debulking surgery). Results: In total, we included 2946 patients. For patients with advanced-stage disease, 52% of the older patients versus 25% of the younger patients did not undergo primary debulking surgery (PDS) or interval debulking surgery (IDS). For patients undergoing PDS or IDS, older patients underwent less extensive surgery and more often had residual disease after surgery >0 cm compared to younger patients. Furthermore, older patients were less often treated with chemotherapy. Older patients had PDS later than younger. We did not find any differences between age groups concerning treatment delays. Two-year cancer-specific survival differed significantly between age groups regardless of curatively intended treatment. Discussion: This study demonstrates that older patients are treated less actively concerning surgical and oncological treatment than younger patients, leading to worse cancer-specific survival. Older patients do not experience more treatment delays than younger ones.

Original languageEnglish
Article number101359
JournalJournal of Geriatric Oncology
Volume14
Issue number1
Number of pages8
ISSN1879-4068
DOIs
Publication statusPublished - 2023

Bibliographical note

Publisher Copyright:
© 2022 The Author(s)

Keywords

  • Chemotherapy
  • Debulking surgery
  • Epithelial ovarian cancer
  • Survival
  • Time to treatment

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