Impact of trial design on the estimation of drug potency and power in clinical trials of haemophilia with inhibitors

Malte Selch Larsen; Rasmus Vestergaard Juul; Mads Kreilgaard; Annemarie T. Kristensen; Ulrika S. H. Simonsson

doi:10.1016/j.ejps.2018.07.056

Impact of trial design on the estimation of drug potency and power in clinical trials of haemophilia with inhibitors

Malte Selch Larsen, Rasmus Vestergaard Juul, Mads Kreilgaard, Annemarie T. Kristensen, Ulrika S. H. Simonsson

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Original language	English
Journal	European Journal of Pharmaceutical Sciences
Volume	123
Pages (from-to)	531-538
ISSN	0928-0987
DOIs	https://doi.org/10.1016/j.ejps.2018.07.056
Publication status	Published - 15 Oct 2018

Keywords

Haemophilia with inhibitors
Clinical trial design
Repeated time-to-event modelling
Drug potency
Statistical power

Access to Document

10.1016/j.ejps.2018.07.056

Cite this

Impact of trial design on the estimation of drug potency and power in clinical trials of haemophilia with inhibitors. / Larsen, Malte Selch; Juul, Rasmus Vestergaard; Kreilgaard, Mads; Kristensen, Annemarie T.; Simonsson, Ulrika S. H.

In: European Journal of Pharmaceutical Sciences, Vol. 123, 15.10.2018, p. 531-538.

Research output: Contribution to journal › Journal article › Research › peer-review

@article{ac1c481724a54d319c76fe271b8c6b20,

title = "Impact of trial design on the estimation of drug potency and power in clinical trials of haemophilia with inhibitors",

keywords = "Haemophilia with inhibitors, Clinical trial design, Repeated time-to-event modelling, Drug potency, Statistical power",

author = "Larsen, {Malte Selch} and Juul, {Rasmus Vestergaard} and Mads Kreilgaard and Kristensen, {Annemarie T.} and Simonsson, {Ulrika S. H.}",

year = "2018",

month = oct,

day = "15",

doi = "10.1016/j.ejps.2018.07.056",

language = "English",

volume = "123",

pages = "531--538",

journal = "Norvegica Pharmaceutica Acta",

issn = "0928-0987",

publisher = "Elsevier",

}

TY - JOUR

T1 - Impact of trial design on the estimation of drug potency and power in clinical trials of haemophilia with inhibitors

AU - Larsen, Malte Selch

AU - Juul, Rasmus Vestergaard

AU - Kreilgaard, Mads

AU - Kristensen, Annemarie T.

AU - Simonsson, Ulrika S. H.

PY - 2018/10/15

Y1 - 2018/10/15

KW - Haemophilia with inhibitors

KW - Clinical trial design

KW - Repeated time-to-event modelling

KW - Drug potency

KW - Statistical power

U2 - 10.1016/j.ejps.2018.07.056

DO - 10.1016/j.ejps.2018.07.056

M3 - Journal article

C2 - 30077714

VL - 123

SP - 531

EP - 538

JO - Norvegica Pharmaceutica Acta

JF - Norvegica Pharmaceutica Acta

SN - 0928-0987

ER -