Impaired crosstalk between pulsatile insulin and glucagon secretion in prediabetic individuals

Stefan Rohrer; Björn A Menge; Lena Grüber; Carolyn F Deacon; Wolfgang E Schmidt; Johannes D Veldhuis; Jens Juul Holst; Juris J Meier

doi:10.1210/jc.2011-3439

Impaired crosstalk between pulsatile insulin and glucagon secretion in prediabetic individuals

Stefan Rohrer, Björn A Menge, Lena Grüber, Carolyn F Deacon, Wolfgang E Schmidt, Johannes D Veldhuis, Jens Juul Holst, Juris J Meier

Endocrinology and Metabolism

Research output: Contribution to journal › Journal article › Research › peer-review

37 Citations (Scopus)

Abstract

Postprandial hyperglucagonemia is frequently found in patients with diabetes. Recently, a loss of the inverse relationship between pulsatile insulin and glucagon secretion has been reported in patients with type 2 diabetes. The crosstalk between pulsatile islet hormone secretion in prediabetic individuals has not yet been examined.

Original language	English
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	97
Issue number	5
Pages (from-to)	E791-E795
ISSN	0021-972X
DOIs	https://doi.org/10.1210/jc.2011-3439
Publication status	Published - 2012

Keywords

Adult
Aged
Blood Glucose
Female
Glucagon
Glucose Tolerance Test
Humans
Insulin
Male
Middle Aged
Postprandial Period
Prediabetic State

Access to Document

10.1210/jc.2011-3439

Cite this

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abstract = "Postprandial hyperglucagonemia is frequently found in patients with diabetes. Recently, a loss of the inverse relationship between pulsatile insulin and glucagon secretion has been reported in patients with type 2 diabetes. The crosstalk between pulsatile islet hormone secretion in prediabetic individuals has not yet been examined.",

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AU - Rohrer, Stefan

AU - Menge, Björn A

AU - Grüber, Lena

AU - Deacon, Carolyn F

AU - Schmidt, Wolfgang E

AU - Veldhuis, Johannes D

AU - Holst, Jens Juul

AU - Meier, Juris J

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KW - Adult

KW - Aged

KW - Blood Glucose

KW - Female

KW - Glucagon

KW - Glucose Tolerance Test

KW - Humans

KW - Insulin

KW - Male

KW - Middle Aged

KW - Postprandial Period

KW - Prediabetic State

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DO - 10.1210/jc.2011-3439

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