Implementation of a combinatorial cleavage and deprotection scheme. 1. Synthesis of phthalhydrazine libraries

John Nielsen; P. H. Rasmussen

doi:10.1016/0040-4039(96)00544-8

Implementation of a combinatorial cleavage and deprotection scheme. 1. Synthesis of phthalhydrazine libraries

John Nielsen^*, P. H. Rasmussen

^*Corresponding author for this work

Natural Products and Peptides

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22 Citations (Scopus)

Abstract

Phthalhydrazine libraries are synthesized in solution from substituted hydrazines and phthalimides in several different library formats including single compounds, indexed sub-libraries and a full library. When carried out during solid-phase synthesis, this combinatorial cleavage and deprotection scheme offers the possibility for generating a diverse library of substituted phthalhydrazides.

Original language	English
Journal	Tetrahedron Letters
Volume	37
Issue number	19
Pages (from-to)	3351-3354
Number of pages	4
ISSN	0040-4039
DOIs	https://doi.org/10.1016/0040-4039(96)00544-8
Publication status	Published - 1 Jan 1996

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abstract = "Phthalhydrazine libraries are synthesized in solution from substituted hydrazines and phthalimides in several different library formats including single compounds, indexed sub-libraries and a full library. When carried out during solid-phase synthesis, this combinatorial cleavage and deprotection scheme offers the possibility for generating a diverse library of substituted phthalhydrazides.",

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AB - Phthalhydrazine libraries are synthesized in solution from substituted hydrazines and phthalimides in several different library formats including single compounds, indexed sub-libraries and a full library. When carried out during solid-phase synthesis, this combinatorial cleavage and deprotection scheme offers the possibility for generating a diverse library of substituted phthalhydrazides.

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