In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B

Eleni Kontogiannidou; Thomas Meikopoulos; Helen Gika; Emmanuel Panteris; Ioannis S Vizirianakis; Anette Müllertz; Dimitrios G Fatouros

doi:10.3390/pharmaceutics12080699

In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B

Eleni Kontogiannidou, Thomas Meikopoulos, Helen Gika, Emmanuel Panteris, Ioannis S Vizirianakis, Anette Müllertz, Dimitrios G Fatouros

Physiological Pharmaceutics

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Abstract

Amphotericin B (AmpB), one of the most commonly used agents in the treatment of severe fungal infections and life-threatening parasitic diseases such as visceral Leishmaniasis, has a negligible oral bioavailability, primarily due to a low solubility and permeability. To develop an oral formulation, medium chain triglycerides and nonionic surfactants in a self-nano-emulsifying drug delivery system (SNEDDS) containing AmpB were combined with room temperature ionic liquids (RTILs) of imidazolium. The presence of ionic liquids significantly enhanced the solubility of AmpB, exhibited a low toxicity and increased the transport of AmpB across Caco-2 cell monolayers. The combination of RTILs with a lipid formulation might be a promising strategy to improve the oral bioavailability of AmpB.

Original language	English
Journal	Pharmaceutics
Volume	12
Issue number	8
Number of pages	14
ISSN	1999-4923
DOIs	https://doi.org/10.3390/pharmaceutics12080699
Publication status	Published - 2020

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Cite this

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title = "In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B",

abstract = "Amphotericin B (AmpB), one of the most commonly used agents in the treatment of severe fungal infections and life-threatening parasitic diseases such as visceral Leishmaniasis, has a negligible oral bioavailability, primarily due to a low solubility and permeability. To develop an oral formulation, medium chain triglycerides and nonionic surfactants in a self-nano-emulsifying drug delivery system (SNEDDS) containing AmpB were combined with room temperature ionic liquids (RTILs) of imidazolium. The presence of ionic liquids significantly enhanced the solubility of AmpB, exhibited a low toxicity and increased the transport of AmpB across Caco-2 cell monolayers. The combination of RTILs with a lipid formulation might be a promising strategy to improve the oral bioavailability of AmpB.",

author = "Eleni Kontogiannidou and Thomas Meikopoulos and Helen Gika and Emmanuel Panteris and Vizirianakis, {Ioannis S} and Anette M{\"u}llertz and Fatouros, {Dimitrios G}",

year = "2020",

doi = "10.3390/pharmaceutics12080699",

language = "English",

volume = "12",

journal = "Pharmaceutics",

issn = "1999-4923",

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T1 - In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B

AU - Kontogiannidou, Eleni

AU - Meikopoulos, Thomas

AU - Gika, Helen

AU - Panteris, Emmanuel

AU - Vizirianakis, Ioannis S

AU - Müllertz, Anette

AU - Fatouros, Dimitrios G

PY - 2020

Y1 - 2020

N2 - Amphotericin B (AmpB), one of the most commonly used agents in the treatment of severe fungal infections and life-threatening parasitic diseases such as visceral Leishmaniasis, has a negligible oral bioavailability, primarily due to a low solubility and permeability. To develop an oral formulation, medium chain triglycerides and nonionic surfactants in a self-nano-emulsifying drug delivery system (SNEDDS) containing AmpB were combined with room temperature ionic liquids (RTILs) of imidazolium. The presence of ionic liquids significantly enhanced the solubility of AmpB, exhibited a low toxicity and increased the transport of AmpB across Caco-2 cell monolayers. The combination of RTILs with a lipid formulation might be a promising strategy to improve the oral bioavailability of AmpB.

AB - Amphotericin B (AmpB), one of the most commonly used agents in the treatment of severe fungal infections and life-threatening parasitic diseases such as visceral Leishmaniasis, has a negligible oral bioavailability, primarily due to a low solubility and permeability. To develop an oral formulation, medium chain triglycerides and nonionic surfactants in a self-nano-emulsifying drug delivery system (SNEDDS) containing AmpB were combined with room temperature ionic liquids (RTILs) of imidazolium. The presence of ionic liquids significantly enhanced the solubility of AmpB, exhibited a low toxicity and increased the transport of AmpB across Caco-2 cell monolayers. The combination of RTILs with a lipid formulation might be a promising strategy to improve the oral bioavailability of AmpB.

U2 - 10.3390/pharmaceutics12080699

DO - 10.3390/pharmaceutics12080699

M3 - Journal article

C2 - 32722400

SN - 1999-4923

VL - 12

JO - Pharmaceutics

JF - Pharmaceutics

IS - 8

ER -