TY - JOUR
T1 - In-vitro evaluation of the P-glycoprotein interactions of a series of potentially CNS-active Amaryllidaceae alkaloids
AU - Eriksson, André Huss
AU - Rønsted, Nina
AU - Jäger, Anna Katharina
AU - Sendra, Júlia Rodríguez
AU - Brodin, Birger
N1 - © 2012 The Authors. JPP © 2012 Royal Pharmaceutical Society.
PY - 2012
Y1 - 2012
N2 - Drug compounds interacting with the blood-brain barrier efflux transporter P-glycoprotein (P-gp) might have limited access to brain tissue. The aim of the present study was to evaluate whether nine potentially CNS-active Amaryllidaceae alkaloids of the crinine, lycorine and galanthamine types interact with P-gp.
AB - Drug compounds interacting with the blood-brain barrier efflux transporter P-glycoprotein (P-gp) might have limited access to brain tissue. The aim of the present study was to evaluate whether nine potentially CNS-active Amaryllidaceae alkaloids of the crinine, lycorine and galanthamine types interact with P-gp.
U2 - 10.1111/j.2042-7158.2012.01536.x
DO - 10.1111/j.2042-7158.2012.01536.x
M3 - Journal article
C2 - 23058055
VL - 64
SP - 1667
EP - 1677
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
SN - 0022-3573
IS - 11
ER -