In-vitro evaluation of the P-glycoprotein interactions of a series of potentially CNS-active Amaryllidaceae alkaloids

André Huss Eriksson, Nina Rønsted, Anna Katharina Jäger, Júlia Rodríguez Sendra, Birger Brodin

Research output: Contribution to journalJournal articleResearchpeer-review

15 Citations (Scopus)

Abstract

Drug compounds interacting with the blood-brain barrier efflux transporter P-glycoprotein (P-gp) might have limited access to brain tissue. The aim of the present study was to evaluate whether nine potentially CNS-active Amaryllidaceae alkaloids of the crinine, lycorine and galanthamine types interact with P-gp.
Original languageEnglish
JournalJournal of Pharmacy and Pharmacology
Volume64
Issue number11
Pages (from-to)1667-1677
Number of pages11
ISSN0022-3573
DOIs
Publication statusPublished - 2012

Cite this