In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR                         120                         ) in Aspergillus Fumigatus cyp51A, Denmark

Rasmus K. Hare; Jan B. Gertsen; Karen M.T. Astvad; Kristine B. Degn; Anders Løkke; Marc Stegger; Paal S. Andersen; Lise Kristensen; Maiken C. Arendrup

doi:10.3201/eid2503.180297

In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR ₁₂₀ ) in Aspergillus Fumigatus cyp51A, Denmark

Rasmus K. Hare^*, Jan B. Gertsen, Karen M.T. Astvad, Kristine B. Degn, Anders Løkke, Marc Stegger, Paal S. Andersen, Lise Kristensen, Maiken C. Arendrup

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

43 Citations (Scopus)

20 Downloads (Pure)

Abstract

We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus.

Original language	English
Journal	Emerging Infectious Diseases
Volume	25
Issue number	3
Pages (from-to)	577-580
ISSN	1080-6040
DOIs	https://doi.org/10.3201/eid2503.180297
Publication status	Published - Mar 2019

Access to Document

10.3201/eid2503.180297Licence: CC0

In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR 120 ) in Aspergillus Fumigatus cyp51A, Denmark_(version_of_record)Final published version, 1.26 MBLicence: CC0

Cite this

Hare, R. K., Gertsen, J. B., Astvad, K. M. T., Degn, K. B., Løkke, A., Stegger, M., Andersen, P. S., Kristensen, L., & Arendrup, M. C. (2019). In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR ₁₂₀ ) in Aspergillus Fumigatus cyp51A, Denmark. Emerging Infectious Diseases , 25(3), 577-580. https://doi.org/10.3201/eid2503.180297

In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR ₁₂₀ ) in Aspergillus Fumigatus cyp51A, Denmark. / Hare, Rasmus K.; Gertsen, Jan B.; Astvad, Karen M.T. et al.
In: Emerging Infectious Diseases , Vol. 25, No. 3, 03.2019, p. 577-580.

Research output: Contribution to journal › Journal article › Research › peer-review

Hare, RK, Gertsen, JB, Astvad, KMT, Degn, KB, Løkke, A, Stegger, M, Andersen, PS, Kristensen, L & Arendrup, MC 2019, 'In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR ₁₂₀ ) in Aspergillus Fumigatus cyp51A, Denmark', Emerging Infectious Diseases , vol. 25, no. 3, pp. 577-580. https://doi.org/10.3201/eid2503.180297

@article{21c40157c4094b76bd101dc935dda5ab,

title = "In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR 120 ) in Aspergillus Fumigatus cyp51A, Denmark",

abstract = "We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus.",

author = "Hare, {Rasmus K.} and Gertsen, {Jan B.} and Astvad, {Karen M.T.} and Degn, {Kristine B.} and Anders L{\o}kke and Marc Stegger and Andersen, {Paal S.} and Lise Kristensen and Arendrup, {Maiken C.}",

year = "2019",

month = mar,

doi = "10.3201/eid2503.180297",

language = "English",

volume = "25",

pages = "577--580",

journal = "Emerging Infectious Diseases ",

issn = "1080-6040",

publisher = "CDC Centers for Disease Control and Prevention",

number = "3",

}

TY - JOUR

T1 - In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR 120 ) in Aspergillus Fumigatus cyp51A, Denmark

AU - Hare, Rasmus K.

AU - Gertsen, Jan B.

AU - Astvad, Karen M.T.

AU - Degn, Kristine B.

AU - Løkke, Anders

AU - Stegger, Marc

AU - Andersen, Paal S.

AU - Kristensen, Lise

AU - Arendrup, Maiken C.

PY - 2019/3

Y1 - 2019/3

N2 - We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus.

AB - We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus.

U2 - 10.3201/eid2503.180297

DO - 10.3201/eid2503.180297

M3 - Journal article

C2 - 30789127

AN - SCOPUS:85061986209

SN - 1080-6040

VL - 25

SP - 577

EP - 580

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 3

ER -