Incidence of HPV-related Anogenital Intraepithelial Neoplasia and Cancer in Men with Diabetes Compared with the General Population

Kristian Reinholdt, Louise Thirstrup Thomsen, Christian Munk, Christian Dehlendorff, Bendix Carstensen, Marit Eika Jørgensen, Susanne Krüger Kjaer*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

5 Citations (Scopus)

Abstract

Background: Diabetes may increase risk of human papillomavirus (HPV)-related precancer and cancer. We estimated incidence of penile and anal high-grade intraepithelial neoplasia (hgPeIN, hgAIN) and squamous cell carcinoma (SCC) in men with diabetes compared with the entire Danish male population without diabetes. Methods: In this registry-based cohort study, we included all men born 1916-2001 and residing in Denmark (n = 2,528,756). From nationwide registries, we retrieved individual-level information on diabetes, educational level, and diagnoses of hgPeIN, hgAIN, penile SCC, and anal SCC. We used Poisson regression models to estimate incidence of hgPeIN, hgAIN, penile SCC, and anal SCC as a function of diabetes status, attained age, calendar period, and education. We estimated incidence rate ratios (IRRs) of each outcome in men with diabetes compared with nondiabetic men, both for diabetes overall and separately for type 1 (T1D) and type 2 diabetes (T2D). Results: Men with diabetes had increased incidence rate of penile SCC compared with nondiabetic men (IRR = 1.5, 95% CI = 1.2, 1.9). We saw similar trends for anal SCC, hgPeIN, and hgAIN. The combined incidence rate of penile and anal SCC was increased in men with T2D (IRR = 1.5, 95% CI = 1.3, 1.8), but not with T1D (IRR = 0.53, 95% CI = 0.20, 1.4) compared with men without diabetes. Conclusion: The incidence of penile and anal high-grade intraepithelial neoplasia and SCC in men with diabetes was increased compared with men without diabetes. For penile and anal SCCs, this was primarily due to an increased risk in men with T2D.

Original languageEnglish
JournalEpidemiology
Volume32
Issue number5
Pages (from-to)705-711
Number of pages7
ISSN1044-3983
DOIs
Publication statusPublished - 2021

Bibliographical note

Publisher Copyright:
© 2021 Wolters Kluwer Health, Inc. All rights reserved.

Keywords

  • Anal
  • Cancer
  • Diabetes
  • High-grade intraepithelial neoplasia
  • Nationwide cohort
  • Penile

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