Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings

Rannveig Viste; Louise F. Follin; Birgitte R. Kornum; Benedicte A. Lie; Marte K. Viken; Per M. Thorsby; Terje Rootwelt; Julie A. E. Christensen; Stine Knudsen-Heier

doi:10.1093/sleep/zsac316

Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings

Rannveig Viste^*, Louise F. Follin, Birgitte R. Kornum, Benedicte A. Lie, Marte K. Viken, Per M. Thorsby, Terje Rootwelt, Julie A. E. Christensen, Stine Knudsen-Heier

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

17 Downloads (Pure)

Abstract

Study Objectives Narcolepsy type 1 (NT1) is characterized by unstable sleep-wake and muscle tonus regulation during sleep. We characterized dream enactment and muscle activity during sleep in a cohort of post-H1N1 NT1 patients and their siblings, and analyzed whether clinical phenotypic characteristics and major risk factors are associated with increased muscle activity. Methods RBD symptoms and polysomnography m. tibialis anterior electromyographical signals [long (0.5-15 s); short (0.1-0.49 s)] were compared between 114 post-H1N1 NT1 patients and 89 non-narcoleptic siblings. Association sub-analyses with RBD symptoms, narcoleptic symptoms, CSF hypocretin-1 levels, and major risk factors [H1N1-(Pandemrix)-vaccination, HLA-DQB1*06:02-positivity] were performed. Results RBD symptoms, REM and NREM long muscle activity indices and REM short muscle activity index were significantly higher in NT1 patients than siblings (all p < 0.001). Patients with undetectable CSF hypocretin-1 levels (

Original language	English
Journal	Sleep
Volume	46
Issue number	3
Number of pages	14
ISSN	0161-8105
DOIs	https://doi.org/10.1093/sleep/zsac316
Publication status	Published - 2023

Keywords

Narcolepsy type 1
NT1
post Pandemrix NT1
muscle activity in sleep
leg movements in sleep
periodic leg movements
dream enactment
REM sleep behavior disorder
CSF hypocretin-1 deficiency
disease continuum in first-degree relatives
RESTLESS LEGS SYNDROME
CSF HYPOCRETIN-1 LEVELS
REM-SLEEP
POST-H1N1 VACCINATION
CHILDHOOD NARCOLEPSY
NORWEGIAN CHILDREN
H1N1 INFLUENZA
T-CELLS
MOVEMENTS
DIAGNOSIS

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Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings. / Viste, Rannveig; Follin, Louise F.; Kornum, Birgitte R.; Lie, Benedicte A.; Viken, Marte K.; Thorsby, Per M.; Rootwelt, Terje; Christensen, Julie A. E.; Knudsen-Heier, Stine.

In: Sleep, Vol. 46, No. 3, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Viste, Rannveig ; Follin, Louise F. ; Kornum, Birgitte R. ; Lie, Benedicte A. ; Viken, Marte K. ; Thorsby, Per M. ; Rootwelt, Terje ; Christensen, Julie A. E. ; Knudsen-Heier, Stine. / Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings. In: Sleep. 2023 ; Vol. 46, No. 3.

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title = "Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings",

abstract = "Study Objectives Narcolepsy type 1 (NT1) is characterized by unstable sleep-wake and muscle tonus regulation during sleep. We characterized dream enactment and muscle activity during sleep in a cohort of post-H1N1 NT1 patients and their siblings, and analyzed whether clinical phenotypic characteristics and major risk factors are associated with increased muscle activity. Methods RBD symptoms and polysomnography m. tibialis anterior electromyographical signals [long (0.5-15 s); short (0.1-0.49 s)] were compared between 114 post-H1N1 NT1 patients and 89 non-narcoleptic siblings. Association sub-analyses with RBD symptoms, narcoleptic symptoms, CSF hypocretin-1 levels, and major risk factors [H1N1-(Pandemrix)-vaccination, HLA-DQB1*06:02-positivity] were performed. Results RBD symptoms, REM and NREM long muscle activity indices and REM short muscle activity index were significantly higher in NT1 patients than siblings (all p < 0.001). Patients with undetectable CSF hypocretin-1 levels (",

keywords = "Narcolepsy type 1, NT1, post Pandemrix NT1, muscle activity in sleep, leg movements in sleep, periodic leg movements, dream enactment, REM sleep behavior disorder, CSF hypocretin-1 deficiency, disease continuum in first-degree relatives, RESTLESS LEGS SYNDROME, CSF HYPOCRETIN-1 LEVELS, REM-SLEEP, POST-H1N1 VACCINATION, CHILDHOOD NARCOLEPSY, NORWEGIAN CHILDREN, H1N1 INFLUENZA, T-CELLS, MOVEMENTS, DIAGNOSIS",

author = "Rannveig Viste and Follin, {Louise F.} and Kornum, {Birgitte R.} and Lie, {Benedicte A.} and Viken, {Marte K.} and Thorsby, {Per M.} and Terje Rootwelt and Christensen, {Julie A. E.} and Stine Knudsen-Heier",

year = "2023",

doi = "10.1093/sleep/zsac316",

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T1 - Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings

AU - Viste, Rannveig

AU - Follin, Louise F.

AU - Kornum, Birgitte R.

AU - Lie, Benedicte A.

AU - Viken, Marte K.

AU - Thorsby, Per M.

AU - Rootwelt, Terje

AU - Christensen, Julie A. E.

AU - Knudsen-Heier, Stine

PY - 2023

Y1 - 2023

N2 - Study Objectives Narcolepsy type 1 (NT1) is characterized by unstable sleep-wake and muscle tonus regulation during sleep. We characterized dream enactment and muscle activity during sleep in a cohort of post-H1N1 NT1 patients and their siblings, and analyzed whether clinical phenotypic characteristics and major risk factors are associated with increased muscle activity. Methods RBD symptoms and polysomnography m. tibialis anterior electromyographical signals [long (0.5-15 s); short (0.1-0.49 s)] were compared between 114 post-H1N1 NT1 patients and 89 non-narcoleptic siblings. Association sub-analyses with RBD symptoms, narcoleptic symptoms, CSF hypocretin-1 levels, and major risk factors [H1N1-(Pandemrix)-vaccination, HLA-DQB1*06:02-positivity] were performed. Results RBD symptoms, REM and NREM long muscle activity indices and REM short muscle activity index were significantly higher in NT1 patients than siblings (all p < 0.001). Patients with undetectable CSF hypocretin-1 levels (

AB - Study Objectives Narcolepsy type 1 (NT1) is characterized by unstable sleep-wake and muscle tonus regulation during sleep. We characterized dream enactment and muscle activity during sleep in a cohort of post-H1N1 NT1 patients and their siblings, and analyzed whether clinical phenotypic characteristics and major risk factors are associated with increased muscle activity. Methods RBD symptoms and polysomnography m. tibialis anterior electromyographical signals [long (0.5-15 s); short (0.1-0.49 s)] were compared between 114 post-H1N1 NT1 patients and 89 non-narcoleptic siblings. Association sub-analyses with RBD symptoms, narcoleptic symptoms, CSF hypocretin-1 levels, and major risk factors [H1N1-(Pandemrix)-vaccination, HLA-DQB1*06:02-positivity] were performed. Results RBD symptoms, REM and NREM long muscle activity indices and REM short muscle activity index were significantly higher in NT1 patients than siblings (all p < 0.001). Patients with undetectable CSF hypocretin-1 levels (

KW - Narcolepsy type 1

KW - NT1

KW - post Pandemrix NT1

KW - muscle activity in sleep

KW - leg movements in sleep

KW - periodic leg movements

KW - dream enactment

KW - REM sleep behavior disorder

KW - CSF hypocretin-1 deficiency

KW - disease continuum in first-degree relatives

KW - RESTLESS LEGS SYNDROME

KW - CSF HYPOCRETIN-1 LEVELS

KW - REM-SLEEP

KW - POST-H1N1 VACCINATION

KW - CHILDHOOD NARCOLEPSY

KW - NORWEGIAN CHILDREN

KW - H1N1 INFLUENZA

KW - T-CELLS

KW - MOVEMENTS

KW - DIAGNOSIS

U2 - 10.1093/sleep/zsac316

DO - 10.1093/sleep/zsac316

M3 - Journal article

C2 - 36562330

VL - 46

JO - Sleep (Online)

JF - Sleep (Online)

SN - 0161-8105

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ER -