Increased Risk of Anemia, Neutropenia, and Thrombocytopenia in People with Human Immunodeficiency Virus and Well-Controlled Viral Replication

Delal Akdag, Andreas Dehlbæk Knudsen, Rebekka Faber Thudium, Ditte Marie Kirkegaard-Klitbo, Chivit Nielsen, Peter Brown, Shoaib Afzal, Børge G. Nordestgaard, Jens Lundgren, Susanne Dam Nielsen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

11 Citations (Scopus)

Abstract

Background: Prior to the introduction of combination antiretroviral therapy (cART), cytopenias were common in people with human immunodeficiency virus (PWH), but it is unknown if well-controlled HIV infection is a risk factor for cytopenia. In this study we aimed to determine if HIV infection is an independent risk factor for anemia, neutropenia, lymphocytopenia, and thrombocytopenia. Methods: PWH with undetectable viral replication and absence of chronic hepatitis infection (n = 796) were recruited from the Copenhagen Comorbidity in HIV Infection (COCOMO) study and matched uninfected controls from the Copenhagen General Population Study (n = 2388). Hematology was analyzed in venous blood samples. Logistic regression analyses adjusted for age, sex, ethnicity, smoking status, alcohol, and high-sensitivity C-reactive protein were performed to determine possible associations between HIV and cytopenias. Results: PWH had a higher prevalence of anemia (6.9% vs 3.4%, P <. 001), neutropenia (1.3% vs 0.2%, P <. 001), and thrombocytopenia (5.5% vs 2.7%, P <. 001) compared with uninfected controls. HIV was independently associated with anemia-Adjusted odds ratio (aOR) of 2.0 (95% confidence interval [CI], 1.4-3.0); neutropenia aOR, 6.3 (95% CI, 2.0-19.6); and thrombocytopenia aOR, 2.7 (95% CI, 1.8-4.2). No association was found between HIV and lymphocytopenia. Conclusions: Cytopenia is rare in people with well-controlled HIV, but HIV remains a risk factor for anemia, neutropenia, and thrombocytopenia and requires ongoing attention and monitoring.

Original languageEnglish
JournalJournal of Infectious Diseases
Volume220
Issue number11
Pages (from-to)1834-1842
Number of pages9
ISSN0022-1899
DOIs
Publication statusPublished - 2019

Keywords

  • Anemia
  • Cytopenia
  • HIV
  • Lymphocytopenia
  • Neutropenia
  • Thrombocytopenia

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