Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy

Anders B Klein; Poul Jennum; Stine Knudsen; Steen Gammeltoft; Jens D Mikkelsen

doi:10.1016/j.neulet.2013.03.031

Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy

Anders B Klein, Poul Jennum, Stine Knudsen, Steen Gammeltoft, Jens D Mikkelsen

Research output: Contribution to journal › Journal article › Research › peer-review

14 Citations (Scopus)

Abstract

Narcolepsy is a lifelong sleep disorder characterized by excessive daytime sleepiness, sudden loss of muscle tone (cataplexy), fragmentation of nocturnal sleep and sleep paralysis. The symptoms of the disease strongly correlate with a reduction in hypocretin levels in CSF and a reduction in hypocretin neurons in hypothalamus in post-mortem tissue. Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are important for activity-dependent neuronal function and synaptic modulation and it is considered that these mechanisms are important in sleep regulation. We hypothesised that serum levels of these factors are altered in patients with narcolepsy compared to healthy controls without sleep disturbances. Polysomnography data was obtained and serum BDNF and NGF levels measured using ELISA, while hypocretin was measured using RIA. Serum BDNF levels were significantly higher in narcolepsy patients than in healthy controls (64.2±3.9ng/ml vs 47.3±2.6ng/ml, P

Original language	English
Journal	Neuroscience Letters
Volume	544
Pages (from-to)	31-35
Number of pages	5
ISSN	0304-3940
DOIs	https://doi.org/10.1016/j.neulet.2013.03.031
Publication status	Published - 7 Jun 2013

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10.1016/j.neulet.2013.03.031

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title = "Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy",

abstract = "Narcolepsy is a lifelong sleep disorder characterized by excessive daytime sleepiness, sudden loss of muscle tone (cataplexy), fragmentation of nocturnal sleep and sleep paralysis. The symptoms of the disease strongly correlate with a reduction in hypocretin levels in CSF and a reduction in hypocretin neurons in hypothalamus in post-mortem tissue. Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are important for activity-dependent neuronal function and synaptic modulation and it is considered that these mechanisms are important in sleep regulation. We hypothesised that serum levels of these factors are altered in patients with narcolepsy compared to healthy controls without sleep disturbances. Polysomnography data was obtained and serum BDNF and NGF levels measured using ELISA, while hypocretin was measured using RIA. Serum BDNF levels were significantly higher in narcolepsy patients than in healthy controls (64.2±3.9ng/ml vs 47.3±2.6ng/ml, P",

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T1 - Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy

AU - Klein, Anders B

AU - Jennum, Poul

AU - Knudsen, Stine

AU - Gammeltoft, Steen

AU - Mikkelsen, Jens D

PY - 2013/6/7

Y1 - 2013/6/7

N2 - Narcolepsy is a lifelong sleep disorder characterized by excessive daytime sleepiness, sudden loss of muscle tone (cataplexy), fragmentation of nocturnal sleep and sleep paralysis. The symptoms of the disease strongly correlate with a reduction in hypocretin levels in CSF and a reduction in hypocretin neurons in hypothalamus in post-mortem tissue. Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are important for activity-dependent neuronal function and synaptic modulation and it is considered that these mechanisms are important in sleep regulation. We hypothesised that serum levels of these factors are altered in patients with narcolepsy compared to healthy controls without sleep disturbances. Polysomnography data was obtained and serum BDNF and NGF levels measured using ELISA, while hypocretin was measured using RIA. Serum BDNF levels were significantly higher in narcolepsy patients than in healthy controls (64.2±3.9ng/ml vs 47.3±2.6ng/ml, P

AB - Narcolepsy is a lifelong sleep disorder characterized by excessive daytime sleepiness, sudden loss of muscle tone (cataplexy), fragmentation of nocturnal sleep and sleep paralysis. The symptoms of the disease strongly correlate with a reduction in hypocretin levels in CSF and a reduction in hypocretin neurons in hypothalamus in post-mortem tissue. Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are important for activity-dependent neuronal function and synaptic modulation and it is considered that these mechanisms are important in sleep regulation. We hypothesised that serum levels of these factors are altered in patients with narcolepsy compared to healthy controls without sleep disturbances. Polysomnography data was obtained and serum BDNF and NGF levels measured using ELISA, while hypocretin was measured using RIA. Serum BDNF levels were significantly higher in narcolepsy patients than in healthy controls (64.2±3.9ng/ml vs 47.3±2.6ng/ml, P

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DO - 10.1016/j.neulet.2013.03.031

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