Indomethacin decreases optic nerve oxygen tension by a mechanism other than cyclo-oxygenase inhibition

M Hove Noergaard; D Bach Pedersen; K Bang; Peter Koch Jensen; Jens Folke Kiilgaard; E Stefánsson; M la Cour

doi:10.1136/bjo.2007.122309

Indomethacin decreases optic nerve oxygen tension by a mechanism other than cyclo-oxygenase inhibition

M Hove Noergaard, D Bach Pedersen, K Bang, Peter Koch Jensen, Jens Folke Kiilgaard, E Stefánsson, M la Cour

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

Abstract

We investigated the effect of several Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), on the preoptic nerve oxygen tension (ONPO2), as indomethacin previously has demonstrated a strong decreasing effect on ONPO2. We tested whether these NSAIDs, like indomethacin, also reduce the increasing effect of dorzolamide on ONPO2.

Original language	English
Journal	British Journal of Ophthalmology
Volume	92
Issue number	1
Pages (from-to)	126-30
Number of pages	5
ISSN	0007-1161
DOIs	https://doi.org/10.1136/bjo.2007.122309 https://doi.org/10.1136/bjo.2007.122309
Publication status	Published - 2008

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title = "Indomethacin decreases optic nerve oxygen tension by a mechanism other than cyclo-oxygenase inhibition",

abstract = "We investigated the effect of several Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), on the preoptic nerve oxygen tension (ONPO2), as indomethacin previously has demonstrated a strong decreasing effect on ONPO2. We tested whether these NSAIDs, like indomethacin, also reduce the increasing effect of dorzolamide on ONPO2.",

author = "Noergaard, {M Hove} and Pedersen, {D Bach} and K Bang and Jensen, {Peter Koch} and Kiilgaard, {Jens Folke} and E Stef{\'a}nsson and {la Cour}, M",

note = "IS - 1468-2079 (Electronic)LA - engPT - Journal ArticlePT - Research Support, Non-U.S. Gov'tRN - 0 (Anti-Inflammatory Agents, Non-Steroidal)RN - 0 (Cyclooxygenase Inhibitors)RN - 124-38-9 (Carbon Dioxide)RN - 53-86-1 (Indomethacin)RN - 7782-44-7 (Oxygen)SB - IM",

year = "2008",

doi = "10.1136/bjo.2007.122309",

language = "English",

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T1 - Indomethacin decreases optic nerve oxygen tension by a mechanism other than cyclo-oxygenase inhibition

AU - Noergaard, M Hove

AU - Pedersen, D Bach

AU - Bang, K

AU - Jensen, Peter Koch

AU - Kiilgaard, Jens Folke

AU - Stefánsson, E

AU - la Cour, M

N1 - IS - 1468-2079 (Electronic)LA - engPT - Journal ArticlePT - Research Support, Non-U.S. Gov'tRN - 0 (Anti-Inflammatory Agents, Non-Steroidal)RN - 0 (Cyclooxygenase Inhibitors)RN - 124-38-9 (Carbon Dioxide)RN - 53-86-1 (Indomethacin)RN - 7782-44-7 (Oxygen)SB - IM

PY - 2008

Y1 - 2008

N2 - We investigated the effect of several Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), on the preoptic nerve oxygen tension (ONPO2), as indomethacin previously has demonstrated a strong decreasing effect on ONPO2. We tested whether these NSAIDs, like indomethacin, also reduce the increasing effect of dorzolamide on ONPO2.

AB - We investigated the effect of several Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), on the preoptic nerve oxygen tension (ONPO2), as indomethacin previously has demonstrated a strong decreasing effect on ONPO2. We tested whether these NSAIDs, like indomethacin, also reduce the increasing effect of dorzolamide on ONPO2.

U2 - 10.1136/bjo.2007.122309

DO - 10.1136/bjo.2007.122309

M3 - Journal article

C2 - 17965100

SN - 0007-1161

VL - 92

SP - 126

EP - 130

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

IS - 1

ER -