TY - JOUR
T1 - Inflammatory markers in relation to maternal lifestyle and adverse pregnancy outcomes in twin pregnancies
AU - Christiansen, Cecilie Holm
AU - Kirk, Mille
AU - Worda, Katharina
AU - Hegaard, Hanne Kristine
AU - Rode, Line
AU - Larsen, Helle
AU - Holmskov, Anni
AU - Andreasen, Kirsten Riis
AU - Uldbjerg, Niels
AU - Ramb, Jan
AU - Sperling, Lene
AU - Hinterberger, Stefan
AU - Krebs, Lone
AU - Zingenberg, Helle
AU - Weiss, Eva Christine
AU - Strobl, Isolde
AU - Laursen, Lone
AU - Christensen, Jeanette Tranberg
AU - Skogstrand, Kristin
AU - Vogel, Ida
AU - Krampl-Bettelheim, Elisabeth
AU - Tabor, Ann
AU - Collaborators – The PREDICT-group
N1 - Publisher Copyright:
© 2024 Elsevier B.V.
PY - 2024
Y1 - 2024
N2 - It is well known that inflammatory markers play an important role in the development and maintenance of healthy pregnancies. However, the literature regarding inflammation in relation to lifestyle and adverse pregnancy outcomes in twin pregnancies is remarkably uncovered. Therefore, this study aimed at evaluating the concentration of inflammatory markers in dried capillary blood spot samples from 523 women with twin pregnancies, included at a median gestational age of 21+1 weeks. The relationship between inflammatory markers and maternal lifestyle (current smoking status and pre-pregnancy body mass index) in addition to adverse pregnancy outcomes (preeclampsia, gestational diabetes mellitus, and small for gestational age) was analyzed. The study showed that active smoking at inclusion was associated with an elevated concentration of interleukin-8. Furthermore, maternal obesity was associated with an elevated concentration of C-reactive protein and monocyte chemoattractant protein-1. Analysis of the data showed no statistically significant variations in the concentration of the assessed inflammatory markers for neither preeclampsia, gestational diabetes mellitus, nor small for gestational age. The current study promotes future research on the pathophysiology of twin pregnancies in relation to adverse pregnancy outcomes, as the literature within the area remains scarce.
AB - It is well known that inflammatory markers play an important role in the development and maintenance of healthy pregnancies. However, the literature regarding inflammation in relation to lifestyle and adverse pregnancy outcomes in twin pregnancies is remarkably uncovered. Therefore, this study aimed at evaluating the concentration of inflammatory markers in dried capillary blood spot samples from 523 women with twin pregnancies, included at a median gestational age of 21+1 weeks. The relationship between inflammatory markers and maternal lifestyle (current smoking status and pre-pregnancy body mass index) in addition to adverse pregnancy outcomes (preeclampsia, gestational diabetes mellitus, and small for gestational age) was analyzed. The study showed that active smoking at inclusion was associated with an elevated concentration of interleukin-8. Furthermore, maternal obesity was associated with an elevated concentration of C-reactive protein and monocyte chemoattractant protein-1. Analysis of the data showed no statistically significant variations in the concentration of the assessed inflammatory markers for neither preeclampsia, gestational diabetes mellitus, nor small for gestational age. The current study promotes future research on the pathophysiology of twin pregnancies in relation to adverse pregnancy outcomes, as the literature within the area remains scarce.
KW - Gestational diabetes
KW - Inflammation
KW - Preeclampsia
KW - Small for gestational age
KW - Twin pregnancy
U2 - 10.1016/j.jri.2024.104286
DO - 10.1016/j.jri.2024.104286
M3 - Journal article
C2 - 38964134
AN - SCOPUS:85197211697
VL - 164
JO - Journal of Reproductive Immunology
JF - Journal of Reproductive Immunology
SN - 0165-0378
M1 - 104286
ER -