Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation

Jonas Goldin Diness; Ulrik S Sørensen; Jakob Dahl Nissen; Baha Al-Shahib; Thomas Jespersen; Morten Grunnet; Rie Schultz Hansen; Thomas Jespersen

doi:10.1161/CIRCEP.110.957407

Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation

Jonas Goldin Diness, Ulrik S Sørensen, Jakob Dahl Nissen, Baha Al-Shahib, Thomas Jespersen, Morten Grunnet, Rie Schultz Hansen, Thomas Jespersen

Physiology of circulation, kidney and lung

Research output: Contribution to journal › Journal article › Research › peer-review

166 Citations (Scopus)

Abstract

Recently, evidence has emerged that small-conductance Ca(2+)-activated K(+) (SK) channels are predominantly expressed in the atria in a number of species including human. In rat, guinea pig, and rabbit ex vivo and in vivo models of atrial fibrillation (AF), we used 3 different SK channel inhibitors, UCL1684, N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (ICA), and NS8593, to assess the hypothesis that pharmacological inhibition of SK channels is antiarrhythmic.

Original language	English
Journal	Circulation. Arrhythmia and electrophysiology
Volume	3
Issue number	4
Pages (from-to)	380-90
Number of pages	11
DOIs	https://doi.org/10.1161/CIRCEP.110.957407
Publication status	Published - Aug 2010

Keywords

1-Naphthylamine
Acetylcholine
Action Potentials
Alkanes
Animals
Anti-Arrhythmia Agents
Atrial Fibrillation
Cardiac Pacing, Artificial
Dose-Response Relationship, Drug
Electrocardiography
Female
Guinea Pigs
Male
Myocardium
Perfusion
Potassium Channel Blockers
Potassium Channels, Calcium-Activated
Pyridines
Quinolinium Compounds
Rabbits
Rats
Rats, Sprague-Dawley
Thiazoles
Time Factors

Access to Document

10.1161/CIRCEP.110.957407

Cite this

Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation. / Diness, Jonas Goldin; Sørensen, Ulrik S; Nissen, Jakob Dahl; Al-Shahib, Baha; Jespersen, Thomas; Grunnet, Morten; Hansen, Rie Schultz; Jespersen, Thomas.

In: Circulation. Arrhythmia and electrophysiology, Vol. 3, No. 4, 08.2010, p. 380-90.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Recently, evidence has emerged that small-conductance Ca(2+)-activated K(+) (SK) channels are predominantly expressed in the atria in a number of species including human. In rat, guinea pig, and rabbit ex vivo and in vivo models of atrial fibrillation (AF), we used 3 different SK channel inhibitors, UCL1684, N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (ICA), and NS8593, to assess the hypothesis that pharmacological inhibition of SK channels is antiarrhythmic.",

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