InPhocus: Current State and Challenges of Phage Research in Singapore

Navin Kumar Verma; Si Jia Tan; John Chen; Hanrong Chen; Muhammad Hafiz Ismail; Scott A Rice; Pablo Bifani; Sukumar Hariharan; Vivek Daniel Paul; Bharathi Sriram; Linh Chi Dam; Chia Ching Chan; Peiying Ho; Boon Chong Goh; Shimin Jasmine Chung; Kenneth Choon Meng Goh; Shu Hua Thong; Andrea Lay Hoon Kwa; Adam Ostrowski; Thet Tun Aung; Halimah Razali; Shermaine W. Y. Low; Mani Shankar Bhattacharyya; Hemant K. Gautam; Rajamani Lakshminarayanan; Thomas Sicheritz-Pontén; Martha R. J. Clokie; Wilfried Moreira; Maurice Adrianus Monique Van Steensel

doi:10.1089/phage.2022.29028.nkv

InPhocus: Current State and Challenges of Phage Research in Singapore

Navin Kumar Verma^*, Si Jia Tan, John Chen, Hanrong Chen, Muhammad Hafiz Ismail, Scott A Rice, Pablo Bifani, Sukumar Hariharan, Vivek Daniel Paul, Bharathi Sriram, Linh Chi Dam, Chia Ching Chan, Peiying Ho, Boon Chong Goh, Shimin Jasmine Chung, Kenneth Choon Meng Goh, Shu Hua Thong, Andrea Lay Hoon Kwa, Adam Ostrowski, Thet Tun AungHalimah Razali, Shermaine W. Y. Low, Mani Shankar Bhattacharyya, Hemant K. Gautam, Rajamani Lakshminarayanan, Thomas Sicheritz-Pontén, Martha R. J. Clokie, Wilfried Moreira, Maurice Adrianus Monique Van Steensel

^*Corresponding author for this work

Section for Hologenomics

Research output: Contribution to journal › Journal article › Research › peer-review

11 Downloads (Pure)

Abstract

Bacteriophages and phage-derived proteins are a promising class of antibacterial agents that experience a growing worldwide interest. To map ongoing phage research in Singapore and neighboring countries, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore (NTU) and Yong Loo Lin School of Medicine, National University of Singapore (NUS) recently co-organized a virtual symposium on Bacteriophage and Bacteriophage-Derived Technologies, which was attended by more than 80 participants. Topics were discussed relating to phage life cycles, diversity, the roles of phages in biofilms and the human gut microbiome, engineered phage lysins to combat polymicrobial infections in wounds, and the challenges and prospects of clinical phage therapy. This perspective summarizes major points discussed during the symposium and new perceptions that emerged after the panel discussion.

Original language	English
Journal	PHAGE: Therapy, Applications, and Research
Volume	3
Issue number	1
Pages (from-to)	6-11
Number of pages	6
ISSN	2641-6530
DOIs	https://doi.org/10.1089/phage.2022.29028.nkv
Publication status	Published - 2022

Bibliographical note

Publisher Copyright:
© 2022, Mary Ann Liebert, Inc., publishers 2022.

Keywords

antimicrobial resistance
ectolysin
filamentous phages
metagenomics
recombinant phage proteins

Access to Document

10.1089/phage.2022.29028.nkv

FulltextFinal published version, 354 KBLicence: Other

Cite this

Verma, N. K., Tan, S. J., Chen, J., Chen, H., Ismail, M. H., Rice, S. A., Bifani, P., Hariharan, S., Paul, V. D., Sriram, B., Dam, L. C., Chan, C. C., Ho, P., Goh, B. C., Chung, S. J., Goh, K. C. M., Thong, S. H., Kwa, A. L. H., Ostrowski, A., ... Van Steensel, M. A. M. (2022). InPhocus: Current State and Challenges of Phage Research in Singapore. PHAGE: Therapy, Applications, and Research, 3(1), 6-11. https://doi.org/10.1089/phage.2022.29028.nkv

InPhocus : Current State and Challenges of Phage Research in Singapore. / Verma, Navin Kumar; Tan, Si Jia; Chen, John; Chen, Hanrong; Ismail, Muhammad Hafiz; Rice, Scott A; Bifani, Pablo; Hariharan, Sukumar; Paul, Vivek Daniel; Sriram, Bharathi; Dam, Linh Chi; Chan, Chia Ching; Ho, Peiying; Goh, Boon Chong; Chung, Shimin Jasmine; Goh, Kenneth Choon Meng; Thong, Shu Hua; Kwa, Andrea Lay Hoon; Ostrowski, Adam; Aung, Thet Tun; Razali, Halimah; Low, Shermaine W. Y.; Bhattacharyya, Mani Shankar; Gautam, Hemant K.; Lakshminarayanan, Rajamani; Sicheritz-Pontén, Thomas; Clokie, Martha R. J.; Moreira, Wilfried; Van Steensel, Maurice Adrianus Monique.

In: PHAGE: Therapy, Applications, and Research, Vol. 3, No. 1, 2022, p. 6-11.

Research output: Contribution to journal › Journal article › Research › peer-review

Verma, NK, Tan, SJ, Chen, J, Chen, H, Ismail, MH, Rice, SA, Bifani, P, Hariharan, S, Paul, VD, Sriram, B, Dam, LC, Chan, CC, Ho, P, Goh, BC, Chung, SJ, Goh, KCM, Thong, SH, Kwa, ALH, Ostrowski, A, Aung, TT, Razali, H, Low, SWY, Bhattacharyya, MS, Gautam, HK, Lakshminarayanan, R, Sicheritz-Pontén, T, Clokie, MRJ, Moreira, W & Van Steensel, MAM 2022, 'InPhocus: Current State and Challenges of Phage Research in Singapore', PHAGE: Therapy, Applications, and Research, vol. 3, no. 1, pp. 6-11. https://doi.org/10.1089/phage.2022.29028.nkv

Verma, Navin Kumar ; Tan, Si Jia ; Chen, John ; Chen, Hanrong ; Ismail, Muhammad Hafiz ; Rice, Scott A ; Bifani, Pablo ; Hariharan, Sukumar ; Paul, Vivek Daniel ; Sriram, Bharathi ; Dam, Linh Chi ; Chan, Chia Ching ; Ho, Peiying ; Goh, Boon Chong ; Chung, Shimin Jasmine ; Goh, Kenneth Choon Meng ; Thong, Shu Hua ; Kwa, Andrea Lay Hoon ; Ostrowski, Adam ; Aung, Thet Tun ; Razali, Halimah ; Low, Shermaine W. Y. ; Bhattacharyya, Mani Shankar ; Gautam, Hemant K. ; Lakshminarayanan, Rajamani ; Sicheritz-Pontén, Thomas ; Clokie, Martha R. J. ; Moreira, Wilfried ; Van Steensel, Maurice Adrianus Monique. / InPhocus : Current State and Challenges of Phage Research in Singapore. In: PHAGE: Therapy, Applications, and Research. 2022 ; Vol. 3, No. 1. pp. 6-11.

@article{cfb29fc7090e4edb98ce31f389d926d4,

title = "InPhocus: Current State and Challenges of Phage Research in Singapore",

abstract = "Bacteriophages and phage-derived proteins are a promising class of antibacterial agents that experience a growing worldwide interest. To map ongoing phage research in Singapore and neighboring countries, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore (NTU) and Yong Loo Lin School of Medicine, National University of Singapore (NUS) recently co-organized a virtual symposium on Bacteriophage and Bacteriophage-Derived Technologies, which was attended by more than 80 participants. Topics were discussed relating to phage life cycles, diversity, the roles of phages in biofilms and the human gut microbiome, engineered phage lysins to combat polymicrobial infections in wounds, and the challenges and prospects of clinical phage therapy. This perspective summarizes major points discussed during the symposium and new perceptions that emerged after the panel discussion. ",

keywords = "antimicrobial resistance, ectolysin, filamentous phages, metagenomics, recombinant phage proteins",

author = "Verma, {Navin Kumar} and Tan, {Si Jia} and John Chen and Hanrong Chen and Ismail, {Muhammad Hafiz} and Rice, {Scott A} and Pablo Bifani and Sukumar Hariharan and Paul, {Vivek Daniel} and Bharathi Sriram and Dam, {Linh Chi} and Chan, {Chia Ching} and Peiying Ho and Goh, {Boon Chong} and Chung, {Shimin Jasmine} and Goh, {Kenneth Choon Meng} and Thong, {Shu Hua} and Kwa, {Andrea Lay Hoon} and Adam Ostrowski and Aung, {Thet Tun} and Halimah Razali and Low, {Shermaine W. Y.} and Bhattacharyya, {Mani Shankar} and Gautam, {Hemant K.} and Rajamani Lakshminarayanan and Thomas Sicheritz-Pont{\'e}n and Clokie, {Martha R. J.} and Wilfried Moreira and {Van Steensel}, {Maurice Adrianus Monique}",

note = "Publisher Copyright: {\textcopyright} 2022, Mary Ann Liebert, Inc., publishers 2022.",

year = "2022",

doi = "10.1089/phage.2022.29028.nkv",

language = "English",

volume = "3",

pages = "6--11",

journal = "PHAGE: Therapy, Applications, and Research",

issn = "2641-6530",

publisher = "Mary AnnLiebert, Inc. Publishers",

number = "1",

}

TY - JOUR

T1 - InPhocus

T2 - Current State and Challenges of Phage Research in Singapore

AU - Verma, Navin Kumar

AU - Tan, Si Jia

AU - Chen, John

AU - Chen, Hanrong

AU - Ismail, Muhammad Hafiz

AU - Rice, Scott A

AU - Bifani, Pablo

AU - Hariharan, Sukumar

AU - Paul, Vivek Daniel

AU - Sriram, Bharathi

AU - Dam, Linh Chi

AU - Chan, Chia Ching

AU - Ho, Peiying

AU - Goh, Boon Chong

AU - Chung, Shimin Jasmine

AU - Goh, Kenneth Choon Meng

AU - Thong, Shu Hua

AU - Kwa, Andrea Lay Hoon

AU - Ostrowski, Adam

AU - Aung, Thet Tun

AU - Razali, Halimah

AU - Low, Shermaine W. Y.

AU - Bhattacharyya, Mani Shankar

AU - Gautam, Hemant K.

AU - Lakshminarayanan, Rajamani

AU - Sicheritz-Pontén, Thomas

AU - Clokie, Martha R. J.

AU - Moreira, Wilfried

AU - Van Steensel, Maurice Adrianus Monique

PY - 2022

Y1 - 2022

N2 - Bacteriophages and phage-derived proteins are a promising class of antibacterial agents that experience a growing worldwide interest. To map ongoing phage research in Singapore and neighboring countries, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore (NTU) and Yong Loo Lin School of Medicine, National University of Singapore (NUS) recently co-organized a virtual symposium on Bacteriophage and Bacteriophage-Derived Technologies, which was attended by more than 80 participants. Topics were discussed relating to phage life cycles, diversity, the roles of phages in biofilms and the human gut microbiome, engineered phage lysins to combat polymicrobial infections in wounds, and the challenges and prospects of clinical phage therapy. This perspective summarizes major points discussed during the symposium and new perceptions that emerged after the panel discussion.

AB - Bacteriophages and phage-derived proteins are a promising class of antibacterial agents that experience a growing worldwide interest. To map ongoing phage research in Singapore and neighboring countries, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore (NTU) and Yong Loo Lin School of Medicine, National University of Singapore (NUS) recently co-organized a virtual symposium on Bacteriophage and Bacteriophage-Derived Technologies, which was attended by more than 80 participants. Topics were discussed relating to phage life cycles, diversity, the roles of phages in biofilms and the human gut microbiome, engineered phage lysins to combat polymicrobial infections in wounds, and the challenges and prospects of clinical phage therapy. This perspective summarizes major points discussed during the symposium and new perceptions that emerged after the panel discussion.

KW - antimicrobial resistance

KW - ectolysin

KW - filamentous phages

KW - metagenomics

KW - recombinant phage proteins

U2 - 10.1089/phage.2022.29028.nkv

DO - 10.1089/phage.2022.29028.nkv

M3 - Journal article

C2 - 36161195

AN - SCOPUS:85132015433

VL - 3

SP - 6

EP - 11

JO - PHAGE: Therapy, Applications, and Research

JF - PHAGE: Therapy, Applications, and Research

SN - 2641-6530

IS - 1

ER -