TY - JOUR
T1 - Insight into Nanoscale Network of Spray-dried Polymeric Particles
T2 - Role of Polymer Molecular Conformation
AU - Wan, Feng
AU - Larsen, Flemming Hofmann
AU - Nunes Bordallo, Heloisa
AU - Foged, Camilla
AU - Rantanen, Jukka
AU - Yang, Mingshi
PY - 2018
Y1 - 2018
N2 - Poly (DL-lactic-co-glycolic acid) (PLGA) microparticles represent a promising formulation approach for providing steady pharmacokinetic/pharmacodynamic profiles of therapeutic drugs for a long period. Understanding and controlling the supramolecular structure of PLGA microparticles at a molecular level is a prerequisite for the rational design of well-controlled, reproducible sustained-release profiles. Herein, we reveal that the role of PLGA molecular conformation in particle formation and drug release. The nanoscale mobility of PLGA microparticles spray-dried using the solvents with distinct polarities was investigated by using nuclear magnetic resonance (NMR) and neutron scattering. By employing chemometric method, we further demonstrated the evolution of nanoscale networks in spray-dried PLGA microparticles upon the water absorption. Our results indicate that PLGA molecules form more chain entanglements during spray drying when using the solvents with low polarity, where PLGA molecule adopts a more flexible, extended conformation, resulting in that the more resistant network against the water absorption in the spray-dried PLGA microparticles. This work underlines the role of PLGA molecular conformation in controlling formation and evolution of nanoscale network of spray-dried PLGA microparticles and will have important consequences in achieving the customized drug release from PLGA microparticles.
AB - Poly (DL-lactic-co-glycolic acid) (PLGA) microparticles represent a promising formulation approach for providing steady pharmacokinetic/pharmacodynamic profiles of therapeutic drugs for a long period. Understanding and controlling the supramolecular structure of PLGA microparticles at a molecular level is a prerequisite for the rational design of well-controlled, reproducible sustained-release profiles. Herein, we reveal that the role of PLGA molecular conformation in particle formation and drug release. The nanoscale mobility of PLGA microparticles spray-dried using the solvents with distinct polarities was investigated by using nuclear magnetic resonance (NMR) and neutron scattering. By employing chemometric method, we further demonstrated the evolution of nanoscale networks in spray-dried PLGA microparticles upon the water absorption. Our results indicate that PLGA molecules form more chain entanglements during spray drying when using the solvents with low polarity, where PLGA molecule adopts a more flexible, extended conformation, resulting in that the more resistant network against the water absorption in the spray-dried PLGA microparticles. This work underlines the role of PLGA molecular conformation in controlling formation and evolution of nanoscale network of spray-dried PLGA microparticles and will have important consequences in achieving the customized drug release from PLGA microparticles.
U2 - 10.1021/acsami.8b12475
DO - 10.1021/acsami.8b12475
M3 - Journal article
C2 - 30211530
VL - 10
SP - 36686
EP - 36692
JO - ACS applied materials & interfaces
JF - ACS applied materials & interfaces
SN - 1944-8244
IS - 43
ER -