Integrating environmental outcomes in randomised clinical trials: a call to action

Johanne Juul Petersen; Linn Hemberg; Lehana Thabane; Sally Hopewell; An-Wen Chan; Asbjørn Hróbjartsson; Ole Mathiesen; Myles Sergeant; Sujane Kandasamy; Nandi Siegfried; Paula R. Williamson; Lisa Fox; Caroline Barkholt Kamp; Jean Marc Hoffmann; Stig Brorson; Peter Bentzer; Janus Christian Jakobsen

doi:10.1016/S0140-6736(24)02666-7

Integrating environmental outcomes in randomised clinical trials: a call to action

Johanne Juul Petersen^*, Linn Hemberg, Lehana Thabane, Sally Hopewell, An-Wen Chan, Asbjørn Hróbjartsson, Ole Mathiesen, Myles Sergeant, Sujane Kandasamy, Nandi Siegfried, Paula R. Williamson, Lisa Fox, Caroline Barkholt Kamp, Jean Marc Hoffmann, Stig Brorson, Peter Bentzer, Janus Christian Jakobsen

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › Research › peer-review

Abstract

The use of the Earth's resources has overstepped several planetary boundaries. We are at risk of destabilising the planet with devastating consequences on the climate and other aspects of the environment.1 This process will adversely affect human health through interconnected effects such as food insecurity, extreme weather events, and the spread of infectious diseases.2 WHO has declared climate change the defining issue for public health and labelled the Paris Agreement the potentially strongest health-care agreement of this century.3 Health care is a resource-intensive activity with a substantial environmental impact, accounting for more than 4% of global carbon emissions.4 Improved sustainability of health care is essential to safeguard the health of current and future generations.

Original language	English
Journal	The Lancet
Volume	405
Issue number	10477
Pages (from-to)	446-448
Number of pages	3
ISSN	0140-6736
DOIs	https://doi.org/10.1016/S0140-6736(24)02666-7
Publication status	Published - 2025

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10.1016/S0140-6736(24)02666-7

Cite this

Petersen, J. J., Hemberg, L., Thabane, L., Hopewell, S., Chan, A-W., Hróbjartsson, A., Mathiesen, O., Sergeant, M., Kandasamy, S., Siegfried, N., Williamson, P. R., Fox, L., Kamp, C. B., Hoffmann, J. M., Brorson, S., Bentzer, P., & Jakobsen, J. C. (2025). Integrating environmental outcomes in randomised clinical trials: a call to action. The Lancet, 405(10477), 446-448. https://doi.org/10.1016/S0140-6736(24)02666-7

Integrating environmental outcomes in randomised clinical trials : a call to action. / Petersen, Johanne Juul; Hemberg, Linn; Thabane, Lehana; Hopewell, Sally; Chan, An-Wen; Hróbjartsson, Asbjørn; Mathiesen, Ole; Sergeant, Myles; Kandasamy, Sujane; Siegfried, Nandi; Williamson, Paula R.; Fox, Lisa; Kamp, Caroline Barkholt; Hoffmann, Jean Marc; Brorson, Stig; Bentzer, Peter; Jakobsen, Janus Christian.

In: The Lancet, Vol. 405, No. 10477, 2025, p. 446-448.

Research output: Contribution to journal › Comment/debate › Research › peer-review

Petersen, JJ, Hemberg, L, Thabane, L, Hopewell, S, Chan, A-W, Hróbjartsson, A, Mathiesen, O, Sergeant, M, Kandasamy, S, Siegfried, N, Williamson, PR, Fox, L, Kamp, CB, Hoffmann, JM, Brorson, S, Bentzer, P & Jakobsen, JC 2025, 'Integrating environmental outcomes in randomised clinical trials: a call to action', The Lancet, vol. 405, no. 10477, pp. 446-448. https://doi.org/10.1016/S0140-6736(24)02666-7

Petersen, Johanne Juul ; Hemberg, Linn ; Thabane, Lehana ; Hopewell, Sally ; Chan, An-Wen ; Hróbjartsson, Asbjørn ; Mathiesen, Ole ; Sergeant, Myles ; Kandasamy, Sujane ; Siegfried, Nandi ; Williamson, Paula R. ; Fox, Lisa ; Kamp, Caroline Barkholt ; Hoffmann, Jean Marc ; Brorson, Stig ; Bentzer, Peter ; Jakobsen, Janus Christian. / Integrating environmental outcomes in randomised clinical trials : a call to action. In: The Lancet. 2025 ; Vol. 405, No. 10477. pp. 446-448.

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abstract = "The use of the Earth's resources has overstepped several planetary boundaries. We are at risk of destabilising the planet with devastating consequences on the climate and other aspects of the environment.1 This process will adversely affect human health through interconnected effects such as food insecurity, extreme weather events, and the spread of infectious diseases.2 WHO has declared climate change the defining issue for public health and labelled the Paris Agreement the potentially strongest health-care agreement of this century.3 Health care is a resource-intensive activity with a substantial environmental impact, accounting for more than 4% of global carbon emissions.4 Improved sustainability of health care is essential to safeguard the health of current and future generations.",

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