Integreret diagnostik af hjernetumorer baseret på histologiske og molekylære karakteristika

Jeanette K Petersen; David Scheie; Henning B Boldt; Benedicte P Ulhøi; Marianne S Ettrup; Bjarne W Kristensen

Integreret diagnostik af hjernetumorer baseret på histologiske og molekylære karakteristika

Translated title of the contribution: Integrated diagnostics of brain tumours based on histological and molecular features

Jeanette K Petersen, David Scheie, Henning B Boldt, Benedicte P Ulhøi, Marianne S Ettrup, Bjarne W Kristensen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Diagnostics of tumours of the central nervous system has for decades been based entirely on microscopy. A con-siderable degree of diagnostic interobserver variability has been observed due to imprecise histological criteria. In the revised WHO classification for central nervous system tumours from 2016, several diagnoses are now defined by both histological and molecular features and constitute "integrated diagnoses". The development based on new technologies like next-generation sequencing and DNA methylation profiling is discussed in this review as well as its implication for daily diagnostics and the patient.

Translated title of the contribution	Integrated diagnostics of brain tumours based on histological and molecular features
Original language	Danish
Article number	V07180509
Journal	Ugeskrift for Laeger
Volume	181
Number of pages	5
ISSN	0041-5782
Publication status	Published - 2019

Access to Document

https://ugeskriftet.dk/videnskab/integreret-diagnostik-af-hjernetumorer-baseret-pa-histologiske-og-molekylaere

Cite this

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title = "Integreret diagnostik af hjernetumorer baseret p{\aa} histologiske og molekyl{\ae}re karakteristika",

abstract = "Diagnostics of tumours of the central nervous system has for decades been based entirely on microscopy. A con-siderable degree of diagnostic interobserver variability has been observed due to imprecise histological criteria. In the revised WHO classification for central nervous system tumours from 2016, several diagnoses are now defined by both histological and molecular features and constitute {"}integrated diagnoses{"}. The development based on new technologies like next-generation sequencing and DNA methylation profiling is discussed in this review as well as its implication for daily diagnostics and the patient.",

keywords = "Brain Neoplasms/diagnosis, Central Nervous System Neoplasms/diagnosis, Glioma/diagnosis, Humans",

author = "Petersen, {Jeanette K} and David Scheie and Boldt, {Henning B} and Ulh{\o}i, {Benedicte P} and Ettrup, {Marianne S} and Kristensen, {Bjarne W}",

year = "2019",

language = "Dansk",

volume = "181",

journal = "Ugeskrift for Laeger",

issn = "0041-5782",

publisher = "Almindelige Danske Laegeforening",

}

TY - JOUR

T1 - Integreret diagnostik af hjernetumorer baseret på histologiske og molekylære karakteristika

AU - Petersen, Jeanette K

AU - Scheie, David

AU - Boldt, Henning B

AU - Ulhøi, Benedicte P

AU - Ettrup, Marianne S

AU - Kristensen, Bjarne W

PY - 2019

Y1 - 2019

N2 - Diagnostics of tumours of the central nervous system has for decades been based entirely on microscopy. A con-siderable degree of diagnostic interobserver variability has been observed due to imprecise histological criteria. In the revised WHO classification for central nervous system tumours from 2016, several diagnoses are now defined by both histological and molecular features and constitute "integrated diagnoses". The development based on new technologies like next-generation sequencing and DNA methylation profiling is discussed in this review as well as its implication for daily diagnostics and the patient.

AB - Diagnostics of tumours of the central nervous system has for decades been based entirely on microscopy. A con-siderable degree of diagnostic interobserver variability has been observed due to imprecise histological criteria. In the revised WHO classification for central nervous system tumours from 2016, several diagnoses are now defined by both histological and molecular features and constitute "integrated diagnoses". The development based on new technologies like next-generation sequencing and DNA methylation profiling is discussed in this review as well as its implication for daily diagnostics and the patient.

KW - Brain Neoplasms/diagnosis

KW - Central Nervous System Neoplasms/diagnosis

KW - Glioma/diagnosis

KW - Humans

M3 - Tidsskriftartikel

C2 - 30729918

VL - 181

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

SN - 0041-5782

M1 - V07180509

ER -