TY - JOUR
T1 - Interatrial Communications
T2 - Prevalence and Subtypes in 12,385 Newborns–a Copenhagen Baby Heart Study
AU - Blixenkrone-Møller, Elisabeth
AU - Dannesbo, Sofie
AU - Dehn, Anna Maria
AU - Pihl, Christian A.
AU - Sillesen, Anne Sophie
AU - Vøgg, R. Ottilia B.
AU - Raja, Anna Axelsson
AU - Colan, Steven
AU - Mertens, Luc
AU - Vejlstrup, Niels
AU - Bundgaard, Henning
AU - Iversen, Kasper
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024
Y1 - 2024
N2 - The prevalence of interatrial communications in newborns, i.e., patent foramen ovale or atrial septal defect, was previously reported to be between 24 and 92%, but the area has been impeded by lack of a universal classification method. A recently published novel echocardiographic diagnostic algorithm for systematic classification of interatrial communications had inter-and intraobserver agreements superior to standard expert assessment. This study aimed to determine the prevalence of subtypes of interatrial communications on transthoracic echocardiography in newborns. Echocardiograms of newborns aged 0–30 days were prospectively collected in the population-based cohort study Copenhagen Baby Heart Study in 2017–2018 and analyzed according to the new diagnostic algorithm, classifying interatrial communications into three subtypes of patent foramen ovale and three subtypes of atrial septal defects. Echocardiograms from 15,801 newborns were analyzed; 3416 (21.6%) were excluded due to suboptimal image quality or severe structural heart disease (n = 3), leaving 12,385 newborns (aged 12 [interquartile range 8; 15] days, 48.2% female) included in the study. An interatrial communication was detected in 9766 (78.9%) newborns. According to the algorithm, 9029 (72.9%) had a patent foramen ovale, while 737 (6.0%) fulfilled criteria for an atrial septal defect, further divided into subtypes. An interatrial communication was seen on echocardiography in almost 80% of newborns aged 0–30 days. Patent foramen ovale was 12 times more frequent than atrial septal defects. The observed prevalence of atrial septal defects was higher than previously reported. Follow up studies could distinguish which interatrial communications require follow-up or intervention. ClinicalTrial.gov, NCT02753348, posted April 27, 2016, [https://classic.clinicaltrials.gov/ct2/show/NCT02753348].
AB - The prevalence of interatrial communications in newborns, i.e., patent foramen ovale or atrial septal defect, was previously reported to be between 24 and 92%, but the area has been impeded by lack of a universal classification method. A recently published novel echocardiographic diagnostic algorithm for systematic classification of interatrial communications had inter-and intraobserver agreements superior to standard expert assessment. This study aimed to determine the prevalence of subtypes of interatrial communications on transthoracic echocardiography in newborns. Echocardiograms of newborns aged 0–30 days were prospectively collected in the population-based cohort study Copenhagen Baby Heart Study in 2017–2018 and analyzed according to the new diagnostic algorithm, classifying interatrial communications into three subtypes of patent foramen ovale and three subtypes of atrial septal defects. Echocardiograms from 15,801 newborns were analyzed; 3416 (21.6%) were excluded due to suboptimal image quality or severe structural heart disease (n = 3), leaving 12,385 newborns (aged 12 [interquartile range 8; 15] days, 48.2% female) included in the study. An interatrial communication was detected in 9766 (78.9%) newborns. According to the algorithm, 9029 (72.9%) had a patent foramen ovale, while 737 (6.0%) fulfilled criteria for an atrial septal defect, further divided into subtypes. An interatrial communication was seen on echocardiography in almost 80% of newborns aged 0–30 days. Patent foramen ovale was 12 times more frequent than atrial septal defects. The observed prevalence of atrial septal defects was higher than previously reported. Follow up studies could distinguish which interatrial communications require follow-up or intervention. ClinicalTrial.gov, NCT02753348, posted April 27, 2016, [https://classic.clinicaltrials.gov/ct2/show/NCT02753348].
KW - Atrial septal defect
KW - Echocardiography
KW - Interatrial communication
KW - Neonate
KW - Patent foramen ovale
KW - Prevalence
U2 - 10.1007/s00246-024-03571-0
DO - 10.1007/s00246-024-03571-0
M3 - Journal article
C2 - 39003423
AN - SCOPUS:85198414129
JO - Pediatric Cardiology
JF - Pediatric Cardiology
SN - 0172-0643
ER -