Is high oily fish intake achievable and how does it affect nutrient status in 8-9-year-old children? : the FiSK Junior trial

Stine Vuholm*, Marie Nygaard Teisen, Nanna Glent Buch, Ken D Stark, Jette Jakobsen, Christian Mølgaard, Lotte Lauritzen, Camilla Trab Damsgaard

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

13 Citations (Scopus)
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Abstract

Purpose: Most children do not meet dietary guidelines for fish intake. Fish is the main source of EPA (20:5n-3), DHA (22:6n-3) and vitamin D, but may replace better iron sources such as meat. We investigated if intake of 300 g/week oily fish was achievable in children and how it affected their nutrient status. Additionally, we validated a fish food frequency questionnaire (FFQ) by correlations against EPA + DHA in red blood cells (RBC).

Methods: In a randomised 12-week trial, 199 children (8-9 years) received oily fish or poultry (control) to be eaten five times/week. We measured dietary intake and analysed fasting RBC EPA + DHA, serum 25-hydroxyvitamin D (25(OH)D), blood haemoglobin and plasma ferritin.

Results: 197 (99%) children completed the study. The median (25th-75th percentile) intake was 375 (325-426) and 400 (359-452) g/week oily fish and poultry, respectively. The fish group increased their intake of EPA + DHA by 749 (593-891) mg/day and vitamin D by 3.1 (1.6-3.8) µg/day. Endpoint RBC EPA + DHA was 2.3 (95% CI 1.9; 2.6) fatty acid %-point higher than the poultry group (P < 0.001). The fish group avoided the expected 25(OH)D winter decline (P < 0.001) and had 23%-point less vitamin D insufficiency (winter subgroup, n = 82). Haemoglobin and ferritin decreased slightly in both groups (P < 0.05), but the number of children with low values did not change (P > 0.14). FFQ estimates moderately reflected habitual intake (r = 0.28-0.35) and sufficiently captured intervention-introduced changes in intake (r > 0.65).

Conclusion: Oily fish intake of 300 g/week was achievable and improved children's EPA + DHA and 25(OH)D status, without markedly compromising iron status. These results justify public health initiatives focusing on children's fish intake.

Original languageEnglish
JournalEuropean Journal of Nutrition
Volume59
Issue number3
Pages (from-to)1205-1218
Number of pages14
ISSN1436-6207
DOIs
Publication statusPublished - 2020

Keywords

  • Faculty of Science
  • Docosahexaenoic acid (DHA)
  • Eicosapentaenoic acid (EPA)
  • Vitamin D
  • Iron
  • n-3 Long-chain polyunsaturated fatty acids (n-3 LCPUFA)

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