Islet-cell dysfunction induced by glucocorticoid treatment: potential role for altered sympathovagal balance?

Daniël H van Raalte; Kelly A A Kwa; Renate E van Genugten; Maarten E Tushuizen; Jens Juul Holst; Carolyn F Deacon; John M Karemaker; Robert J Heine; Andrea Mari; Michaela Diamant

doi:10.1016/j.metabol.2012.10.007

Islet-cell dysfunction induced by glucocorticoid treatment: potential role for altered sympathovagal balance?

Daniël H van Raalte, Kelly A A Kwa, Renate E van Genugten, Maarten E Tushuizen, Jens Juul Holst, Carolyn F Deacon, John M Karemaker, Robert J Heine, Andrea Mari, Michaela Diamant

Research output: Contribution to journal › Journal article › Research › peer-review

28 Citations (Scopus)

Abstract

Glucocorticoids impair glucose tolerance by inducing insulin resistance. We investigated the dose-dependent effects of glucocorticoid treatment on islet-cell function in healthy males and studied the role of the autonomic nervous system.

Original language	English
Journal	Metabolism
Volume	62
Issue number	4
Pages (from-to)	568-577
Number of pages	10
ISSN	0026-0495
DOIs	https://doi.org/10.1016/j.metabol.2012.10.007
Publication status	Published - 2013

Keywords

Adolescent
Adult
Anthropometry
Arginine
Blood Glucose
Dose-Response Relationship, Drug
Double-Blind Method
Glucagon
Glucocorticoids
Glucose Clamp Technique
Heart Rate
Humans
Hyperglycemia
Incretins
Islets of Langerhans
Male
Pancreatic Diseases
Pancreatic Function Tests
Prednisolone
Stimulation, Chemical
Sympathetic Nervous System
Vagus Nerve
Young Adult

Access to Document

10.1016/j.metabol.2012.10.007

Cite this

@article{ec19b70a4ad4424db4ec8dda80b05ff4,

title = "Islet-cell dysfunction induced by glucocorticoid treatment: potential role for altered sympathovagal balance?",

abstract = "Glucocorticoids impair glucose tolerance by inducing insulin resistance. We investigated the dose-dependent effects of glucocorticoid treatment on islet-cell function in healthy males and studied the role of the autonomic nervous system.",

keywords = "Adolescent, Adult, Anthropometry, Arginine, Blood Glucose, Dose-Response Relationship, Drug, Double-Blind Method, Glucagon, Glucocorticoids, Glucose Clamp Technique, Heart Rate, Humans, Hyperglycemia, Incretins, Islets of Langerhans, Male, Pancreatic Diseases, Pancreatic Function Tests, Prednisolone, Stimulation, Chemical, Sympathetic Nervous System, Vagus Nerve, Young Adult",

author = "{van Raalte}, {Dani{\"e}l H} and Kwa, {Kelly A A} and {van Genugten}, {Renate E} and Tushuizen, {Maarten E} and Holst, {Jens Juul} and Deacon, {Carolyn F} and Karemaker, {John M} and Heine, {Robert J} and Andrea Mari and Michaela Diamant",

year = "2013",

doi = "10.1016/j.metabol.2012.10.007",

language = "English",

volume = "62",

pages = "568--577",

journal = "Metabolism",

issn = "0026-0495",

publisher = "Elsevier",

number = "4",

}

TY - JOUR

T1 - Islet-cell dysfunction induced by glucocorticoid treatment

T2 - potential role for altered sympathovagal balance?

AU - van Raalte, Daniël H

AU - Kwa, Kelly A A

AU - van Genugten, Renate E

AU - Tushuizen, Maarten E

AU - Holst, Jens Juul

AU - Deacon, Carolyn F

AU - Karemaker, John M

AU - Heine, Robert J

AU - Mari, Andrea

AU - Diamant, Michaela

PY - 2013

Y1 - 2013

N2 - Glucocorticoids impair glucose tolerance by inducing insulin resistance. We investigated the dose-dependent effects of glucocorticoid treatment on islet-cell function in healthy males and studied the role of the autonomic nervous system.

AB - Glucocorticoids impair glucose tolerance by inducing insulin resistance. We investigated the dose-dependent effects of glucocorticoid treatment on islet-cell function in healthy males and studied the role of the autonomic nervous system.

KW - Adolescent

KW - Adult

KW - Anthropometry

KW - Arginine

KW - Blood Glucose

KW - Dose-Response Relationship, Drug

KW - Double-Blind Method

KW - Glucagon

KW - Glucocorticoids

KW - Glucose Clamp Technique

KW - Heart Rate

KW - Humans

KW - Hyperglycemia

KW - Incretins

KW - Islets of Langerhans

KW - Male

KW - Pancreatic Diseases

KW - Pancreatic Function Tests

KW - Prednisolone

KW - Stimulation, Chemical

KW - Sympathetic Nervous System

KW - Vagus Nerve

KW - Young Adult

U2 - 10.1016/j.metabol.2012.10.007

DO - 10.1016/j.metabol.2012.10.007

M3 - Journal article

C2 - 23164480

SN - 0026-0495

VL - 62

SP - 568

EP - 577

JO - Metabolism

JF - Metabolism

IS - 4

ER -