Isolation of less than Glu-Gly-Leu-Arg-Trp-NH2 (Antho-RWamide II), a novel neuropeptide from sea anemones

Ditte Graff Ebbesen, C J Grimmelikhuijzen

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Abstract

Using a radioimmunoassay for the peptide sequence Arg-Phe-NH2 (RFamide), a novel peptide has been purified from acetic acid extracts of the sea anemone Anthopleura elegantissima. This peptide has the structure less than Glu-Gly-Leu-Arg-Trp-NH2, and was named Antho-RWamide II. Antho-RWamide II is a neuropeptide. Its structure is closely related to an earlier characterized neuropeptide from Anthopleura less than Glu-Ser-Leu-Arg-Trp-NH2 (Antho-RWamide I).
Original languageEnglish
JournalF E B S Letters
Volume239
Issue number1
Pages (from-to)137-40
Number of pages4
ISSN0014-5793
Publication statusPublished - 24 Oct 1988

Keywords

  • Animals
  • Chromatography, High Pressure Liquid
  • Cnidaria
  • Neuropeptides
  • Sea Anemones
  • Structure-Activity Relationship

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