TY - JOUR
T1 - Keratinocyte Carcinoma and Photoprevention
T2 - The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins
AU - Pihl, Celina
AU - Togsverd-Bo, Katrine
AU - Andersen, Flemming
AU - Haedersdal, Merete
AU - Bjerring, Peter
AU - Lerche, Catharina Margrethe
PY - 2021
Y1 - 2021
N2 - Ultraviolet radiation (UVR) arising from sun exposure represents a major risk factor in the development of keratinocyte carcinomas (KCs). UVR exposure induces dysregulated signal transduction, oxidative stress, inflammation, immunosuppression and DNA damage, all of which promote the induction and development of photocarcinogenesis. Because the incidence of KCs is increasing, better prevention strategies are necessary. In the concept of photoprevention, protective compounds are administered either topically or systemically to prevent the effects of UVR and the development of skin cancer. In this review, we provide descriptions of the pathways underlying photocarcinogenesis and an overview of selected photoprotective compounds, such as repurposed pharmaceuticals, plant-derived phytochemicals and vitamins. We discuss the protective potential of these compounds and their effects in pre-clinical and human trials, summarising the mechanisms of action involved in preventing photocarcinogenesis.
AB - Ultraviolet radiation (UVR) arising from sun exposure represents a major risk factor in the development of keratinocyte carcinomas (KCs). UVR exposure induces dysregulated signal transduction, oxidative stress, inflammation, immunosuppression and DNA damage, all of which promote the induction and development of photocarcinogenesis. Because the incidence of KCs is increasing, better prevention strategies are necessary. In the concept of photoprevention, protective compounds are administered either topically or systemically to prevent the effects of UVR and the development of skin cancer. In this review, we provide descriptions of the pathways underlying photocarcinogenesis and an overview of selected photoprotective compounds, such as repurposed pharmaceuticals, plant-derived phytochemicals and vitamins. We discuss the protective potential of these compounds and their effects in pre-clinical and human trials, summarising the mechanisms of action involved in preventing photocarcinogenesis.
KW - Faculty of Health and Medical Sciences
KW - Photoprotection
KW - keratinocyte carcinoma
KW - UV radiation
U2 - 10.3390/cancers13153684
DO - 10.3390/cancers13153684
M3 - Review
C2 - 34359586
VL - 13
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 15
M1 - 3684
ER -