Lack of effect of norepinephrine on cranial haemodynamics and headache in healthy volunteers

M Lindholt; K A Petersen; J F Tvedskov; H K Iversen; J Olesen; P Tfelt-Hansen; Michael Lindholt; Kenneth Ahrend Petersen; J F Tvedskov; Helle Klingenberg Iversen; J Olesen; P Tfelt-Hansen

doi:10.1111/j.1468-2982.2008.01739.x

Lack of effect of norepinephrine on cranial haemodynamics and headache in healthy volunteers

M Lindholt, K A Petersen, J F Tvedskov, H K Iversen, J Olesen, P Tfelt-Hansen, Michael Lindholt, Kenneth Ahrend Petersen, J F Tvedskov, Helle Klingenberg Iversen, J Olesen, P Tfelt-Hansen

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Abstract

Stress is a provoking factor for both tension-type headache and migraine attacks. In the present single-blind study, we investigated if stress induced by norepinephrine (NE) could elicit delayed headache in 10 healthy subjects and recorded the cranial arterial responses. NE at a dose of 0.025 microg kg(-1) min(-1) or placebo was infused for 90 min and the headache was followed for 14 h. Blood flow velocity in the middle cerebral artery (measured with transcranial Doppler) and diameters of the temporal artery and the radial artery (measured with ultrasound) were followed for 2 h. There were no changes in these arterial parameters after NE. In both treatment groups three subjects developed delayed headaches. Thus, stress by NE infusion did not result in delayed headache.

Original language	English
Journal	Cephalalgia
Volume	29
Issue number	3
Pages (from-to)	384-7
Number of pages	3
ISSN	0333-1024
DOIs	https://doi.org/10.1111/j.1468-2982.2008.01739.x https://doi.org/10.1111/j.1468-2982.2008.01739.x
Publication status	Published - 2009

Bibliographical note

Keywords: Adult; Brain; Cerebrovascular Circulation; Cross-Over Studies; Epinephrine; Female; Headache; Hemodynamics; Humans; Male; Middle Cerebral Artery; Radial Artery; Single-Blind Method; Stress, Physiological; Temporal Arteries

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Lindholt, M., Petersen, K. A., Tvedskov, J. F., Iversen, H. K., Olesen, J., Tfelt-Hansen, P., Lindholt, M., Petersen, K. A., Tvedskov, J. F., Iversen, H. K., Olesen, J., & Tfelt-Hansen, P. (2009). Lack of effect of norepinephrine on cranial haemodynamics and headache in healthy volunteers. Cephalalgia, 29(3), 384-7. https://doi.org/10.1111/j.1468-2982.2008.01739.x, https://doi.org/10.1111/j.1468-2982.2008.01739.x

Lack of effect of norepinephrine on cranial haemodynamics and headache in healthy volunteers. / Lindholt, M; Petersen, K A; Tvedskov, J F; Iversen, H K ; Olesen, J; Tfelt-Hansen, P; Lindholt, Michael; Petersen, Kenneth Ahrend; Tvedskov, J F; Iversen, Helle Klingenberg; Olesen, J; Tfelt-Hansen, P.

In: Cephalalgia, Vol. 29, No. 3, 2009, p. 384-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Lindholt, M, Petersen, KA, Tvedskov, JF, Iversen, HK , Olesen, J, Tfelt-Hansen, P, Lindholt, M, Petersen, KA, Tvedskov, JF, Iversen, HK, Olesen, J & Tfelt-Hansen, P 2009, 'Lack of effect of norepinephrine on cranial haemodynamics and headache in healthy volunteers', Cephalalgia, vol. 29, no. 3, pp. 384-7. https://doi.org/10.1111/j.1468-2982.2008.01739.x, https://doi.org/10.1111/j.1468-2982.2008.01739.x

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abstract = "Stress is a provoking factor for both tension-type headache and migraine attacks. In the present single-blind study, we investigated if stress induced by norepinephrine (NE) could elicit delayed headache in 10 healthy subjects and recorded the cranial arterial responses. NE at a dose of 0.025 microg kg(-1) min(-1) or placebo was infused for 90 min and the headache was followed for 14 h. Blood flow velocity in the middle cerebral artery (measured with transcranial Doppler) and diameters of the temporal artery and the radial artery (measured with ultrasound) were followed for 2 h. There were no changes in these arterial parameters after NE. In both treatment groups three subjects developed delayed headaches. Thus, stress by NE infusion did not result in delayed headache.",

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N2 - Stress is a provoking factor for both tension-type headache and migraine attacks. In the present single-blind study, we investigated if stress induced by norepinephrine (NE) could elicit delayed headache in 10 healthy subjects and recorded the cranial arterial responses. NE at a dose of 0.025 microg kg(-1) min(-1) or placebo was infused for 90 min and the headache was followed for 14 h. Blood flow velocity in the middle cerebral artery (measured with transcranial Doppler) and diameters of the temporal artery and the radial artery (measured with ultrasound) were followed for 2 h. There were no changes in these arterial parameters after NE. In both treatment groups three subjects developed delayed headaches. Thus, stress by NE infusion did not result in delayed headache.

AB - Stress is a provoking factor for both tension-type headache and migraine attacks. In the present single-blind study, we investigated if stress induced by norepinephrine (NE) could elicit delayed headache in 10 healthy subjects and recorded the cranial arterial responses. NE at a dose of 0.025 microg kg(-1) min(-1) or placebo was infused for 90 min and the headache was followed for 14 h. Blood flow velocity in the middle cerebral artery (measured with transcranial Doppler) and diameters of the temporal artery and the radial artery (measured with ultrasound) were followed for 2 h. There were no changes in these arterial parameters after NE. In both treatment groups three subjects developed delayed headaches. Thus, stress by NE infusion did not result in delayed headache.

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