TY - JOUR
T1 - Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors
AU - Kjerulff, Bertram
AU - Dowsett, Joseph
AU - Jacobsen, Rikke Louise
AU - Gladov, Josephine
AU - Larsen, Margit Hørup
AU - Lundgaard, Agnete Troen
AU - Banasik, Karina
AU - Westergaard, David
AU - Mikkelsen, Susan
AU - Dinh, Khoa Manh
AU - Hindhede, Lotte
AU - Kaspersen, Kathrine Agergård
AU - Schwinn, Michael
AU - Juul, Anders
AU - Poulsen, Betina
AU - Lindegaard, Birgitte
AU - Pedersen, Carsten Bøcker
AU - Sabel, Clive Eric
AU - Bundgaard, Henning
AU - Nielsen, Henriette Svarre
AU - Møller, Janne Amstrup
AU - Boldsen, Jens Kjærgaard
AU - Burgdorf, Kristoffer Sølvsten
AU - Kessing, Lars Vedel
AU - Handgaard, Linda Jenny
AU - Thørner, Lise Wegner
AU - Didriksen, Maria
AU - Nyegaard, Mette
AU - Grarup, Niels
AU - Ødum, Niels
AU - Johansson, Pär I
AU - Jennum, Poul
AU - Frikke-Schmidt, Ruth
AU - Berger, Sanne Schou
AU - Brunak, Søren
AU - Jacobsen, Søren
AU - Hansen, Thomas Folkmann
AU - Lundquist, Tine Kirkeskov
AU - Hansen, Torben
AU - Sørensen, Torben Lykke
AU - Sigsgaard, Torben
AU - Nielsen, Kaspar René
AU - Bruun, Mie Topholm
AU - Hjalgrim, Henrik
AU - Ullum, Henrik
AU - Rostgaard, Klaus
AU - Sørensen, Erik
AU - Pedersen, Ole Birger
AU - Ostrowski, Sisse Rye
AU - Erikstrup, Christian
N1 - © 2024. The Author(s).
PY - 2024
Y1 - 2024
N2 - BACKGROUND: The emerging use of biomarkers in research and tailored care introduces a need for information about the association between biomarkers and basic demographics and lifestyle factors revealing expectable concentrations in healthy individuals while considering general demographic differences.METHODS: A selection of 47 biomarkers, including markers of inflammation and vascular stress, were measured in plasma samples from 9876 Danish Blood Donor Study participants. Using regression models, we examined the association between biomarkers and sex, age, Body Mass Index (BMI), and smoking.RESULTS: Here we show that concentrations of inflammation and vascular stress biomarkers generally increase with higher age, BMI, and smoking. Sex-specific effects are observed for multiple biomarkers.CONCLUSION: This study provides comprehensive information on concentrations of 47 plasma biomarkers in healthy individuals. The study emphasizes that knowledge about biomarker concentrations in healthy individuals is critical for improved understanding of disease pathology and for tailored care and decision support tools.
AB - BACKGROUND: The emerging use of biomarkers in research and tailored care introduces a need for information about the association between biomarkers and basic demographics and lifestyle factors revealing expectable concentrations in healthy individuals while considering general demographic differences.METHODS: A selection of 47 biomarkers, including markers of inflammation and vascular stress, were measured in plasma samples from 9876 Danish Blood Donor Study participants. Using regression models, we examined the association between biomarkers and sex, age, Body Mass Index (BMI), and smoking.RESULTS: Here we show that concentrations of inflammation and vascular stress biomarkers generally increase with higher age, BMI, and smoking. Sex-specific effects are observed for multiple biomarkers.CONCLUSION: This study provides comprehensive information on concentrations of 47 plasma biomarkers in healthy individuals. The study emphasizes that knowledge about biomarker concentrations in healthy individuals is critical for improved understanding of disease pathology and for tailored care and decision support tools.
U2 - 10.1038/s43856-024-00474-2
DO - 10.1038/s43856-024-00474-2
M3 - Journal article
C2 - 38493237
VL - 4
JO - Communications Medicine
JF - Communications Medicine
SN - 2730-664X
M1 - 50
ER -