Local biochemical and morphological differences in human Achilles tendinopathy: a case control study

Jessica Pingel; U. Fredberg; Klaus Qvortrup; Jytte Overgaard Larsen; Peter Schjerling; Katja Maria Heinemeier; Michael Kjær; Henning Langberg

doi:10.1186/1471-2474-13-53

Local biochemical and morphological differences in human Achilles tendinopathy: a case control study

Jessica Pingel, U. Fredberg, Klaus Qvortrup, Jytte Overgaard Larsen, Peter Schjerling, Katja Maria Heinemeier, Michael Kjær, Henning Langberg

Research output: Contribution to journal › Journal article › Research › peer-review

49 Citations (Scopus)

Abstract

The incidence of Achilles tendinopathy is high and underlying etiology as well as biochemical and morphological pathology associated with the disease is largely unknown. The aim of the present study was to describe biochemical and morphological differences in chronic Achilles tendinopathy. The expressions of growth factors, inflammatory mediators and tendon morphology were determined in both chronically diseased and healthy tendon parts.

Original language	English
Journal	B M C Musculoskeletal Disorders
Volume	13
Issue number	53
Number of pages	14
ISSN	1471-2474
DOIs	https://doi.org/10.1186/1471-2474-13-53
Publication status	Published - 2012

Keywords

Achilles Tendon
Biopsy
Case-Control Studies
Chi-Square Distribution
Chronic Disease
Collagenases
Denmark
Fibrillar Collagens
Gene Expression Regulation
Genetic Markers
Humans
Inflammation Mediators
Intercellular Signaling Peptides and Proteins
Microscopy, Electron, Transmission
Polymerase Chain Reaction
RNA, Messenger
Tendinopathy
Tissue Inhibitor of Metalloproteinases

Access to Document

10.1186/1471-2474-13-53

Cite this

Local biochemical and morphological differences in human Achilles tendinopathy : a case control study. / Pingel, Jessica; Fredberg, U.; Qvortrup, Klaus; Larsen, Jytte Overgaard; Schjerling, Peter; Heinemeier, Katja Maria; Kjær, Michael ; Langberg, Henning.

In: B M C Musculoskeletal Disorders, Vol. 13, No. 53, 2012.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "The incidence of Achilles tendinopathy is high and underlying etiology as well as biochemical and morphological pathology associated with the disease is largely unknown. The aim of the present study was to describe biochemical and morphological differences in chronic Achilles tendinopathy. The expressions of growth factors, inflammatory mediators and tendon morphology were determined in both chronically diseased and healthy tendon parts.",

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AU - Pingel, Jessica

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AU - Qvortrup, Klaus

AU - Larsen, Jytte Overgaard

AU - Schjerling, Peter

AU - Heinemeier, Katja Maria

AU - Kjær, Michael

AU - Langberg, Henning

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AB - The incidence of Achilles tendinopathy is high and underlying etiology as well as biochemical and morphological pathology associated with the disease is largely unknown. The aim of the present study was to describe biochemical and morphological differences in chronic Achilles tendinopathy. The expressions of growth factors, inflammatory mediators and tendon morphology were determined in both chronically diseased and healthy tendon parts.

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KW - Biopsy

KW - Case-Control Studies

KW - Chi-Square Distribution

KW - Chronic Disease

KW - Collagenases

KW - Denmark

KW - Fibrillar Collagens

KW - Gene Expression Regulation

KW - Genetic Markers

KW - Humans

KW - Inflammation Mediators

KW - Intercellular Signaling Peptides and Proteins

KW - Microscopy, Electron, Transmission

KW - Polymerase Chain Reaction

KW - RNA, Messenger

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KW - Tissue Inhibitor of Metalloproteinases

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JO - B M C Musculoskeletal Disorders

JF - B M C Musculoskeletal Disorders

SN - 1471-2474

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