Local release of ATP into the arterial inflow and venous drainage of human skeletal muscle: insight from ATP determination with the intravascular microdialysis technique

Stefan Mortensen, Pia Thaning, Michael Permin Nyberg, Bengt Saltin, Ylva Hellsten

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    Abstract

    Intraluminal ATP could play an important role in the local regulation of skeletal muscle blood flow, but the stimuli that cause ATP release and the levels of plasma ATP in vessels supplying and draining human skeletal muscle remain unclear. To gain insight into the mechanisms by which ATP is released into plasma, we measured plasma [ATP] with the intravascular microdialysis technique at rest and during dynamic exercise (normoxia and hypoxia), passive exercise, thigh compressions and arterial ATP, tyramine and ACh infusion in a total of 16 healthy young men. Femoral arterial and venous[ATP] were 109±34 and 147±45 nmol l(-1) at rest and increased to 363±83 and 560±111 nmol l(-1), respectively, during exercise (P
    Original languageEnglish
    JournalJournal of Physiology
    Volume589
    Issue number7
    Pages (from-to)1847-1857
    Number of pages11
    ISSN0022-3751
    DOIs
    Publication statusPublished - 2011

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