TY - JOUR
T1 - Local release of ATP into the arterial inflow and venous drainage of human skeletal muscle: insight from ATP determination with the intravascular microdialysis technique
AU - Mortensen, Stefan
AU - Thaning, Pia
AU - Nyberg, Michael Permin
AU - Saltin, Bengt
AU - Hellsten, Ylva
N1 - CURIS 2011 5200 018
PY - 2011
Y1 - 2011
N2 - Intraluminal ATP could play an important role in the local regulation of skeletal muscle blood flow, but the stimuli that cause ATP release and the levels of plasma ATP in vessels supplying and draining human skeletal muscle remain unclear. To gain insight into the mechanisms by which ATP is released into plasma, we measured plasma [ATP] with the intravascular microdialysis technique at rest and during dynamic exercise (normoxia and hypoxia), passive exercise, thigh compressions and arterial ATP, tyramine and ACh infusion in a total of 16 healthy young men. Femoral arterial and venous[ATP] were 109±34 and 147±45 nmol l(-1) at rest and increased to 363±83 and 560±111 nmol l(-1), respectively, during exercise (P
AB - Intraluminal ATP could play an important role in the local regulation of skeletal muscle blood flow, but the stimuli that cause ATP release and the levels of plasma ATP in vessels supplying and draining human skeletal muscle remain unclear. To gain insight into the mechanisms by which ATP is released into plasma, we measured plasma [ATP] with the intravascular microdialysis technique at rest and during dynamic exercise (normoxia and hypoxia), passive exercise, thigh compressions and arterial ATP, tyramine and ACh infusion in a total of 16 healthy young men. Femoral arterial and venous[ATP] were 109±34 and 147±45 nmol l(-1) at rest and increased to 363±83 and 560±111 nmol l(-1), respectively, during exercise (P
U2 - 10.1113/jphysiol.2010.203034
DO - 10.1113/jphysiol.2010.203034
M3 - Journal article
C2 - 21300753
VL - 589
SP - 1847
EP - 1857
JO - The Journal of Physiology
JF - The Journal of Physiology
SN - 0022-3751
IS - 7
ER -