Looking into the future of phage-based control of zoonotic pathogens in food and animal production

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Abstract

Using bacteriophages (phages) to control zoonotic pathogens in food and animal production is a realistic and promising antimicrobial approach. Recent studies have demonstrated their efficacy and safety, yet bringing phage products on the market remains a challenge. Here we summarize the procedure for advancing phage applications from the laboratory to simplified model systems and testing in pilot scale, to farms and food industries. We highlight the most important contributions concerning phages in food matrices and animal guts, and propose directions for future research required to understand interactions in such complex systems. Finally, we propose a holistic approach combining a data repository with modelling, multi-omic techniques and data analysis to modernize phage-based control of zoonotic pathogens.

Original languageEnglish
JournalCurrent Opinion in Biotechnology
Volume68
Pages (from-to)96-103
Number of pages8
ISSN0958-1669
DOIs
Publication statusPublished - 2021

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