Loss of control in preschoolers with asthma is a risk factor for disease persistency

Adam Holm-Weber, Louise Aarestrup, Julie Prahl, Mette Hermansen, Kirsten Skamstrup Hansen, Bo Chawes*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Aim: To describe the relationship between loss of control events in preschoolers with asthma and persistence of disease. Methods: We reviewed medical records of children <6 years diagnosed with asthma in 2018 to assess loss of control events during three years of follow-up. Asthma persistency was defined by redeem of short-acting β2-agonist or asthma controllers within one year after the end of follow-up. Logistic regression models were applied to analyse the association between loss of control events and persistence of asthma. Results: We included 172 patients (median age 1.8 years), whereof 126 (73.3%) experienced a loss of control event and 87 (50.6%) had asthma one year after the end of follow-up. Any loss of control event was associated with persistence of asthma adjusted for controller treatment at inclusion, prior exacerbations, atopic comorbidity and caesarean section: aOR, 10.9 (95% CI, 3.9–34.6), p < 0.001. This was also significant restricted to events in the first year of follow-up: 3.52 (1.50–8.67), p < 0.01 and among children only experiencing one event: 6.4 (1.7–27.3), p = 0.01. Conclusion: Loss of control events during a 3-year period among preschoolers with asthma are closely related to disease persistency, which may aid clinicians to assess risk of persistent asthma in young children.

Original languageEnglish
JournalActa Paediatrica, International Journal of Paediatrics
Volume112
Issue number3
Pages (from-to)496-504
Number of pages9
ISSN0803-5253
DOIs
Publication statusPublished - 2023

Bibliographical note

Funding Information:
The current project was done without financial support. All funding received by COPSAC is listed on www.copsac.com .

Publisher Copyright:
© 2022 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

Keywords

  • asthma
  • children
  • loss of control
  • persistence
  • remission

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