Loss of inverse relationship between pulsatile insulin and glucagon secretion in patients with type 2 diabetes

Björn A Menge; Lena Grüber; Signe M Jørgensen; Carolyn F Deacon; Wolfgang E Schmidt; Johannes D Veldhuis; Jens Juul Holst; Juris J Meier

doi:10.2337/db11-0251

Loss of inverse relationship between pulsatile insulin and glucagon secretion in patients with type 2 diabetes

Björn A Menge, Lena Grüber, Signe M Jørgensen, Carolyn F Deacon, Wolfgang E Schmidt, Johannes D Veldhuis, Jens Juul Holst, Juris J Meier

Endocrinology and Metabolism

Research output: Contribution to journal › Journal article › Research › peer-review

111 Citations (Scopus)

Abstract

In patients with type 2 diabetes, glucagon levels are often increased. Furthermore, pulsatile secretion of insulin is disturbed in such patients. Whether pulsatile glucagon secretion is altered in type 2 diabetes is not known.

Original language	English
Journal	Diabetes
Volume	60
Issue number	8
Pages (from-to)	2160-2168
Number of pages	9
ISSN	0046-0192
DOIs	https://doi.org/10.2337/db11-0251
Publication status	Published - Aug 2011

Keywords

Aged
Blood Glucose
Diabetes Mellitus, Type 2
Fasting
Female
Glucagon
Humans
Insulin
Male
Middle Aged
Postprandial Period

Access to Document

10.2337/db11-0251

Cite this

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abstract = "In patients with type 2 diabetes, glucagon levels are often increased. Furthermore, pulsatile secretion of insulin is disturbed in such patients. Whether pulsatile glucagon secretion is altered in type 2 diabetes is not known.",

keywords = "Aged, Blood Glucose, Diabetes Mellitus, Type 2, Fasting, Female, Glucagon, Humans, Insulin, Male, Middle Aged, Postprandial Period",

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AU - Menge, Björn A

AU - Grüber, Lena

AU - Jørgensen, Signe M

AU - Deacon, Carolyn F

AU - Schmidt, Wolfgang E

AU - Veldhuis, Johannes D

AU - Holst, Jens Juul

AU - Meier, Juris J

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KW - Diabetes Mellitus, Type 2

KW - Fasting

KW - Female

KW - Glucagon

KW - Humans

KW - Insulin

KW - Male

KW - Middle Aged

KW - Postprandial Period

U2 - 10.2337/db11-0251

DO - 10.2337/db11-0251

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SN - 0046-0192

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