Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice

Søren Jahn Grubb; Tobias Speerschneider; Dona Occhipinti; Céline Fiset; Søren-Peter Olesen; Morten Bækgaard Thomsen; Kirstine Callø

doi:10.1111/jce.12422

Loss of K⁺ currents in heart failure is accentuated in KChIP2 deficient mice

Søren Jahn Grubb, Tobias Speerschneider, Dona Occhipinti, Céline Fiset, Søren-Peter Olesen, Morten Bækgaard Thomsen, Kirstine Callø

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

Abstract

KV 4 together with KV Channel-Interacting Protein 2 (KChIP2) mediate the fast recovering transient outward potassium current (Ito,f ) in the heart. KChIP2 is downregulated in human heart failure (HF), potentially underlying the loss of Ito,f . We investigated remodeling associated with HF hypothesizing that KChIP2 plays a central role in the modulation of outward K(+) currents in HF.

Original language	English
Journal	Journal of Cardiovascular Electrophysiology
Volume	25
Issue number	8
Pages (from-to)	896-904
Number of pages	9
DOIs	https://doi.org/10.1111/jce.12422
Publication status	Published - 2014

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10.1111/jce.12422

Cite this

Loss of K⁺ currents in heart failure is accentuated in KChIP2 deficient mice. / Grubb, Søren Jahn; Speerschneider, Tobias; Occhipinti, Dona; Fiset, Céline; Olesen, Søren-Peter; Thomsen, Morten Bækgaard ; Callø, Kirstine.

In: Journal of Cardiovascular Electrophysiology, Vol. 25, No. 8, 2014, p. 896-904.

Research output: Contribution to journal › Journal article › Research › peer-review

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AU - Olesen, Søren-Peter

AU - Thomsen, Morten Bækgaard

AU - Callø, Kirstine

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AB - KV 4 together with KV Channel-Interacting Protein 2 (KChIP2) mediate the fast recovering transient outward potassium current (Ito,f ) in the heart. KChIP2 is downregulated in human heart failure (HF), potentially underlying the loss of Ito,f . We investigated remodeling associated with HF hypothesizing that KChIP2 plays a central role in the modulation of outward K(+) currents in HF.

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