Abstract
KV 4 together with KV Channel-Interacting Protein 2 (KChIP2) mediate the fast recovering transient outward potassium current (Ito,f ) in the heart. KChIP2 is downregulated in human heart failure (HF), potentially underlying the loss of Ito,f . We investigated remodeling associated with HF hypothesizing that KChIP2 plays a central role in the modulation of outward K(+) currents in HF.
Original language | English |
---|---|
Journal | Journal of Cardiovascular Electrophysiology |
Volume | 25 |
Issue number | 8 |
Pages (from-to) | 896-904 |
Number of pages | 9 |
DOIs | |
Publication status | Published - 2014 |