Macronutrients and obesity: views, news and reviews

Lise Madsen, Bjørn Liaset, Karsten Kristiansen

Research output: Contribution to journalReviewResearch

6 Citations (Scopus)

Abstract

Profound changes in macronutrient composition of food have taken place since the agricultural revolution, leading to a higher dietary intake of carbohydrates at the expense of protein, and a dramatically increased intake of n-6 polyunsaturated fatty acids (PUFAs) at the expense of n-3 PUFAs. This review focuses on how macronutrients impact on molecular processes central to appetite regulation and energy homeostasis. We discuss the effects on transcription factors, implicated as key players in adipocyte differentiation and function, including PPARs, sterol regulatory element binding proteins and liver X receptors. Furthermore, as energy homeostasis is to a large extent orchestrated by the gut-brain axis, we discuss key hormones involved in the regulation of energy balance and appetite.
Original languageEnglish
JournalFuture Lipidology
Volume3
Issue number1
Pages (from-to)43-74
ISSN1746-0875
DOIs
Publication statusPublished - 2008
Externally publishedYes

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