Many putative endocrine disruptors inhibit prostaglandin synthesis

David M Kristensen, Maria L Skalkam, Karine Marie Laure Audouze, Laurianne Lesné, Christele Desdoits-Lethimonier, Hanne Frederiksen, Søren Brunak, Niels E Skakkebæk, Bernard Jégou, Jacob B. Hansen, Steffen Junker, Henrik Leffers

Research output: Contribution to journalJournal articleResearchpeer-review

83 Citations (Scopus)

Abstract

Prostaglandins (PGs) play key roles in development and maintenance of homeostasis of the adult body. Despite these important roles, it remains unclear whether the PG pathway is a target for endocrine disruption. However, several known endocrine-disrupting compounds (EDCs) share a high degree of structural similarity with mild analgesics.
Original languageEnglish
JournalEnvironmental Health Perspectives
Volume119
Issue number4
Pages (from-to)534-41
Number of pages8
ISSN0091-6765
DOIs
Publication statusPublished - 1 Apr 2011

Keywords

  • Animals
  • Cyclooxygenase 2
  • Dose-Response Relationship, Drug
  • Endocrine Disruptors
  • Fatty Acid Synthesis Inhibitors
  • Humans
  • Male
  • Mast Cells
  • Mice
  • Prostaglandins
  • Rats
  • Testis

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