Many putative endocrine disruptors inhibit prostaglandin synthesis

David M Kristensen; Maria L Skalkam; Karine Marie Laure Audouze; Laurianne Lesné; Christele Desdoits-Lethimonier; Hanne Frederiksen; Søren Brunak; Niels E Skakkebæk; Bernard Jégou; Jacob B. Hansen; Steffen Junker; Henrik Leffers

doi:10.1289/ehp.1002635

Many putative endocrine disruptors inhibit prostaglandin synthesis

David M Kristensen, Maria L Skalkam, Karine Marie Laure Audouze, Laurianne Lesné, Christele Desdoits-Lethimonier, Hanne Frederiksen, Søren Brunak, Niels E Skakkebæk, Bernard Jégou, Jacob B. Hansen, Steffen Junker, Henrik Leffers

Research output: Contribution to journal › Journal article › Research › peer-review

83 Citations (Scopus)

Abstract

Prostaglandins (PGs) play key roles in development and maintenance of homeostasis of the adult body. Despite these important roles, it remains unclear whether the PG pathway is a target for endocrine disruption. However, several known endocrine-disrupting compounds (EDCs) share a high degree of structural similarity with mild analgesics.

Original language	English
Journal	Environmental Health Perspectives
Volume	119
Issue number	4
Pages (from-to)	534-41
Number of pages	8
ISSN	0091-6765
DOIs	https://doi.org/10.1289/ehp.1002635
Publication status	Published - 1 Apr 2011

Keywords

Animals
Cyclooxygenase 2
Dose-Response Relationship, Drug
Endocrine Disruptors
Fatty Acid Synthesis Inhibitors
Humans
Male
Mast Cells
Mice
Prostaglandins
Rats
Testis

Access to Document

10.1289/ehp.1002635

Cite this

Many putative endocrine disruptors inhibit prostaglandin synthesis. / Kristensen, David M; Skalkam, Maria L; Audouze, Karine Marie Laure; Lesné, Laurianne; Desdoits-Lethimonier, Christele; Frederiksen, Hanne; Brunak, Søren ; Skakkebæk, Niels E; Jégou, Bernard; Hansen, Jacob B.; Junker, Steffen; Leffers, Henrik.

In: Environmental Health Perspectives, Vol. 119, No. 4, 01.04.2011, p. 534-41.

Research output: Contribution to journal › Journal article › Research › peer-review

Kristensen, David M ; Skalkam, Maria L ; Audouze, Karine Marie Laure ; Lesné, Laurianne ; Desdoits-Lethimonier, Christele ; Frederiksen, Hanne ; Brunak, Søren ; Skakkebæk, Niels E ; Jégou, Bernard ; Hansen, Jacob B. ; Junker, Steffen ; Leffers, Henrik. / Many putative endocrine disruptors inhibit prostaglandin synthesis. In: Environmental Health Perspectives. 2011 ; Vol. 119, No. 4. pp. 534-41.

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