Maternal and Neonatal Factors Associated with Delayed Closure of Ductus Arteriosus in Term-Born Neonates: Insights from the Copenhagen Baby Heart Cohort Study

Anton Friis Mariager; Alberte Hammeken; Mikkel Malham; Raheel Altaf Raja; Anna Sellmer; Johan Navne; Henning Bundgaard; Kasper Karmark Iversen; Dorthe Lisbeth Jeppesen

doi:10.1159/000543915

Maternal and Neonatal Factors Associated with Delayed Closure of Ductus Arteriosus in Term-Born Neonates: Insights from the Copenhagen Baby Heart Cohort Study

Anton Friis Mariager^*, Alberte Hammeken, Mikkel Malham, Raheel Altaf Raja, Anna Sellmer, Johan Navne, Henning Bundgaard, Kasper Karmark Iversen, Dorthe Lisbeth Jeppesen

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

INTRODUCTION: The prenatal shunt, ductus arteriosus (DA), typically closes during the cardio-pulmonary transition at birth. We evaluated maternal and neonatal factors associated with delayed closure of DA in term-born neonates.

METHODS: We conducted a retrospective cohort study that included full-term neonates from the prospective observational Copenhagen Baby Heart cohort study. We assessed the association between maternal and neonatal factors and delayed ductal closure.

RESULTS: We included 19,566 neonates, of whom 48% were female. Echocardiography was performed at a median age of 12 (IQR: 9-15) and 8 (IQR: 2-13) days for neonates with no DA and an open DA, respectively. Associations with delayed ductal closure included maternal obesity adjusted risk ratio = 2 (95% CI: 1-3.8), maternal hypothyroidism during pregnancy aRR = 2.02 (95% CI: 1.2-3.4), low Apgar 2.6 (95% CI: 1.2-6), high weight aRR = 1.81 (95% CI: 1.2-2.6), and length at birth aRR = 1.7 (95% CI: 1.1-2.6).

CONCLUSION: The identified risk factors for delayed ductal closure in term-born neonates may help increase clinical attention and improve neonatal care.

Original language	English
Journal	Neonatology
Volume	122
Issue number	3
Pages (from-to)	275-280
Number of pages	6
ISSN	1661-7800
DOIs	https://doi.org/10.1159/000543915
Publication status	Published - 2025

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@article{ccf60dff04594b1c869c19bd50579d3c,

title = "Maternal and Neonatal Factors Associated with Delayed Closure of Ductus Arteriosus in Term-Born Neonates: Insights from the Copenhagen Baby Heart Cohort Study",

abstract = "INTRODUCTION: The prenatal shunt, ductus arteriosus (DA), typically closes during the cardio-pulmonary transition at birth. We evaluated maternal and neonatal factors associated with delayed closure of DA in term-born neonates.METHODS: We conducted a retrospective cohort study that included full-term neonates from the prospective observational Copenhagen Baby Heart cohort study. We assessed the association between maternal and neonatal factors and delayed ductal closure.RESULTS: We included 19,566 neonates, of whom 48% were female. Echocardiography was performed at a median age of 12 (IQR: 9-15) and 8 (IQR: 2-13) days for neonates with no DA and an open DA, respectively. Associations with delayed ductal closure included maternal obesity adjusted risk ratio = 2 (95% CI: 1-3.8), maternal hypothyroidism during pregnancy aRR = 2.02 (95% CI: 1.2-3.4), low Apgar 2.6 (95% CI: 1.2-6), high weight aRR = 1.81 (95% CI: 1.2-2.6), and length at birth aRR = 1.7 (95% CI: 1.1-2.6).CONCLUSION: The identified risk factors for delayed ductal closure in term-born neonates may help increase clinical attention and improve neonatal care.",

author = "Mariager, {Anton Friis} and Alberte Hammeken and Mikkel Malham and Raja, {Raheel Altaf} and Anna Sellmer and Johan Navne and Henning Bundgaard and Iversen, {Kasper Karmark} and Jeppesen, {Dorthe Lisbeth}",

note = "{\textcopyright} 2025 The Author(s). Published by S. Karger AG, Basel.",

year = "2025",

doi = "10.1159/000543915",

language = "English",

volume = "122",

pages = "275--280",

journal = "Neonatology",

issn = "1661-7800",

publisher = "S Karger AG",

number = "3",

}

TY - JOUR

T1 - Maternal and Neonatal Factors Associated with Delayed Closure of Ductus Arteriosus in Term-Born Neonates

T2 - Insights from the Copenhagen Baby Heart Cohort Study

AU - Mariager, Anton Friis

AU - Hammeken, Alberte

AU - Malham, Mikkel

AU - Raja, Raheel Altaf

AU - Sellmer, Anna

AU - Navne, Johan

AU - Bundgaard, Henning

AU - Iversen, Kasper Karmark

AU - Jeppesen, Dorthe Lisbeth

PY - 2025

Y1 - 2025

N2 - INTRODUCTION: The prenatal shunt, ductus arteriosus (DA), typically closes during the cardio-pulmonary transition at birth. We evaluated maternal and neonatal factors associated with delayed closure of DA in term-born neonates.METHODS: We conducted a retrospective cohort study that included full-term neonates from the prospective observational Copenhagen Baby Heart cohort study. We assessed the association between maternal and neonatal factors and delayed ductal closure.RESULTS: We included 19,566 neonates, of whom 48% were female. Echocardiography was performed at a median age of 12 (IQR: 9-15) and 8 (IQR: 2-13) days for neonates with no DA and an open DA, respectively. Associations with delayed ductal closure included maternal obesity adjusted risk ratio = 2 (95% CI: 1-3.8), maternal hypothyroidism during pregnancy aRR = 2.02 (95% CI: 1.2-3.4), low Apgar 2.6 (95% CI: 1.2-6), high weight aRR = 1.81 (95% CI: 1.2-2.6), and length at birth aRR = 1.7 (95% CI: 1.1-2.6).CONCLUSION: The identified risk factors for delayed ductal closure in term-born neonates may help increase clinical attention and improve neonatal care.

AB - INTRODUCTION: The prenatal shunt, ductus arteriosus (DA), typically closes during the cardio-pulmonary transition at birth. We evaluated maternal and neonatal factors associated with delayed closure of DA in term-born neonates.METHODS: We conducted a retrospective cohort study that included full-term neonates from the prospective observational Copenhagen Baby Heart cohort study. We assessed the association between maternal and neonatal factors and delayed ductal closure.RESULTS: We included 19,566 neonates, of whom 48% were female. Echocardiography was performed at a median age of 12 (IQR: 9-15) and 8 (IQR: 2-13) days for neonates with no DA and an open DA, respectively. Associations with delayed ductal closure included maternal obesity adjusted risk ratio = 2 (95% CI: 1-3.8), maternal hypothyroidism during pregnancy aRR = 2.02 (95% CI: 1.2-3.4), low Apgar 2.6 (95% CI: 1.2-6), high weight aRR = 1.81 (95% CI: 1.2-2.6), and length at birth aRR = 1.7 (95% CI: 1.1-2.6).CONCLUSION: The identified risk factors for delayed ductal closure in term-born neonates may help increase clinical attention and improve neonatal care.

U2 - 10.1159/000543915

DO - 10.1159/000543915

M3 - Journal article

C2 - 39938495

SN - 1661-7800

VL - 122

SP - 275

EP - 280

JO - Neonatology

JF - Neonatology

IS - 3

ER -