MCT1 helps brown fat suck up succinate

Jens Lund; Marie Sophie Isidor; Zachary Gerhart-Hines

doi:10.1038/s42255-024-00979-z

MCT1 helps brown fat suck up succinate

Jens Lund^*, Marie Sophie Isidor^*, Zachary Gerhart-Hines^*

^*Corresponding author for this work

Research output: Contribution to journal › Letter › Research › peer-review

Abstract

Succinate can be released from contracting skeletal muscle and accumulate in brown adipose tissue (BAT) to drive thermogenesis and protect against obesity. A study in this issue of Nature Metabolism uncovers the mechanistic underpinnings of BAT succinate sequestration through MCT1-dependent uptake and cytosolic pH changes, thus strengthening the role for cellular shuttling of succinate in the control of systemic energy homeostasis.

Original language	English
Journal	Nature Metabolism
Volume	6
Pages (from-to)	387–388
ISSN	2522-5812
DOIs	https://doi.org/10.1038/s42255-024-00979-z
Publication status	Published - 2024

Bibliographical note

Publisher Copyright:
© Springer Nature Limited 2024.

Access to Document

10.1038/s42255-024-00979-z

Cite this

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title = "MCT1 helps brown fat suck up succinate",

abstract = "Succinate can be released from contracting skeletal muscle and accumulate in brown adipose tissue (BAT) to drive thermogenesis and protect against obesity. A study in this issue of Nature Metabolism uncovers the mechanistic underpinnings of BAT succinate sequestration through MCT1-dependent uptake and cytosolic pH changes, thus strengthening the role for cellular shuttling of succinate in the control of systemic energy homeostasis.",

author = "Jens Lund and Isidor, {Marie Sophie} and Zachary Gerhart-Hines",

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AU - Lund, Jens

AU - Isidor, Marie Sophie

AU - Gerhart-Hines, Zachary

N1 - Publisher Copyright: © Springer Nature Limited 2024.

PY - 2024

Y1 - 2024

N2 - Succinate can be released from contracting skeletal muscle and accumulate in brown adipose tissue (BAT) to drive thermogenesis and protect against obesity. A study in this issue of Nature Metabolism uncovers the mechanistic underpinnings of BAT succinate sequestration through MCT1-dependent uptake and cytosolic pH changes, thus strengthening the role for cellular shuttling of succinate in the control of systemic energy homeostasis.

AB - Succinate can be released from contracting skeletal muscle and accumulate in brown adipose tissue (BAT) to drive thermogenesis and protect against obesity. A study in this issue of Nature Metabolism uncovers the mechanistic underpinnings of BAT succinate sequestration through MCT1-dependent uptake and cytosolic pH changes, thus strengthening the role for cellular shuttling of succinate in the control of systemic energy homeostasis.

U2 - 10.1038/s42255-024-00979-z

DO - 10.1038/s42255-024-00979-z

M3 - Letter

C2 - 38378995

AN - SCOPUS:85185932267

VL - 6

SP - 387

EP - 388

JO - Nature Metabolism

JF - Nature Metabolism

SN - 2522-5812

ER -