Measurement of the incretin hormones: glucagon-like peptide-1 and glucose-dependent insulinotropic peptide

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Abstract

The two incretin hormones, glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), are secreted from the gastrointestinal tract in response to meals and contribute to the regulation of glucose homeostasis by increasing insulin secretion. Assessment of plasma concentrations of GLP-1 and GIP is often an important endpoint in both clinical and preclinical studies and, therefore, accurate measurement of these hormones is important. Here, we provide an overview of current approaches for the measurement of the incretin hormones, with particular focus on immunological methods.

Original languageEnglish
JournalJournal of Diabetes and its Complications
Volume29
Issue number3
Pages (from-to)445-450
Number of pages6
ISSN1056-8727
DOIs
Publication statusPublished - Apr 2015

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