Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration

Alexander L. Nielsen; Nima Rajabi; Norio Kudo; Kathrine Lundø; Carlos Moreno-Yruela; Michael Bæk; Martin Fontenas; Alessia Lucidi; Andreas S. Madsen; Minoru Yoshida; Christian A. Olsen

doi:10.1039/D0CB00036A

Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration

Alexander L. Nielsen, Nima Rajabi, Norio Kudo, Kathrine Lundø, Carlos Moreno-Yruela, Michael Bæk, Martin Fontenas, Alessia Lucidi, Andreas S. Madsen, Minoru Yoshida, Christian A. Olsen

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

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Original language	English
Journal	RSC Chemical Biology
Volume	2
Pages (from-to)	612-626
DOIs	https://doi.org/10.1039/D0CB00036A
Publication status	Published - 2021

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10.1039/D0CB00036ALicence: CC BY-NC

d0cb00036aFinal published version, 6.95 MBLicence: CC BY-NC

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Nielsen, A. L., Rajabi, N., Kudo, N., Lundø, K., Moreno-Yruela, C., Bæk, M., Fontenas, M., Lucidi, A., Madsen, A. S., Yoshida, M., & Olsen, C. A. (2021). Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration. RSC Chemical Biology, 2, 612-626. https://doi.org/10.1039/D0CB00036A

Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration. / Nielsen, Alexander L.; Rajabi, Nima; Kudo, Norio; Lundø, Kathrine; Moreno-Yruela, Carlos; Bæk, Michael; Fontenas, Martin; Lucidi, Alessia; Madsen, Andreas S.; Yoshida, Minoru; Olsen, Christian A.

In: RSC Chemical Biology, Vol. 2, 2021, p. 612-626.

Research output: Contribution to journal › Journal article › Research › peer-review

Nielsen, AL, Rajabi, N, Kudo, N, Lundø, K, Moreno-Yruela, C, Bæk, M, Fontenas, M, Lucidi, A, Madsen, AS, Yoshida, M & Olsen, CA 2021, 'Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration', RSC Chemical Biology, vol. 2, pp. 612-626. https://doi.org/10.1039/D0CB00036A

Nielsen, Alexander L. ; Rajabi, Nima ; Kudo, Norio ; Lundø, Kathrine ; Moreno-Yruela, Carlos ; Bæk, Michael ; Fontenas, Martin ; Lucidi, Alessia ; Madsen, Andreas S. ; Yoshida, Minoru ; Olsen, Christian A. / Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration. In: RSC Chemical Biology. 2021 ; Vol. 2. pp. 612-626.

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AU - Kudo, Norio

AU - Lundø, Kathrine

AU - Moreno-Yruela, Carlos

AU - Bæk, Michael

AU - Fontenas, Martin

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AU - Madsen, Andreas S.

AU - Yoshida, Minoru

AU - Olsen, Christian A.

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