TY - JOUR
T1 - Mechanisms underlying absent training-induced improvement in insulin action in lean, hyperandrogenic women with polycystic ovary syndrome
AU - Hansen, Solvejg Lis
AU - Bojsen-Møller, Kirstine N
AU - Lundsgaard, Anne-Marie
AU - Hendrich, Frederikke L
AU - Nilas, Lisbeth
AU - Sjøberg, Kim Anker
AU - Hingst, Janne Rasmuss
AU - Serup, Annette Karen
AU - Henríquez-Olguín, Carlos
AU - Carl, Christian Strini
AU - Wernblad, Louise F
AU - Henneberg, Marie
AU - Lustrup, Katja M
AU - Hansen, Christine
AU - Jensen, Thomas Elbenhardt
AU - Madsbad, Sten
AU - Wojtaszewski, Jørgen
AU - Richter, Erik A.
AU - Kiens, Bente
N1 - © 2020 by the American Diabetes Association.
PY - 2020
Y1 - 2020
N2 - Women with polycystic ovary syndrome (PCOS) have been shown to be less insulin sensitive compared with control (CON) women, independent of BMI. Training is associated with molecular adaptations in skeletal muscle, improving glucose uptake and metabolism in both healthy individuals and patients type 2 diabetes. In the current study, lean hyperandrogenic women with PCOS (n = 9) and healthy CON women (n = 9) completed 14 weeks of controlled and supervised exercise training. In CON, the training intervention increased whole body insulin action by 26% and insulin-stimulated leg glucose uptake by 53%, together with increased insulin-stimulated leg blood flow and a more oxidative muscle fiber type distribution. In PCOS, no such changes were found, despite similar training intensity and improvements in VO2max. In skeletal muscle of CON but not PCOS, training increased GLUT4 and HKII mRNA and protein expressions. These data suggest that the impaired increase in whole-body insulin action in women with PCOS with training is caused by an impaired ability to upregulate key glucose-handling proteins for insulin-stimulated glucose uptake in skeletal muscle and insulin-stimulated leg blood flow. Still, other important benefits of exercise training appeared in women with PCOS, including an improvement of the hyperandrogenic state.
AB - Women with polycystic ovary syndrome (PCOS) have been shown to be less insulin sensitive compared with control (CON) women, independent of BMI. Training is associated with molecular adaptations in skeletal muscle, improving glucose uptake and metabolism in both healthy individuals and patients type 2 diabetes. In the current study, lean hyperandrogenic women with PCOS (n = 9) and healthy CON women (n = 9) completed 14 weeks of controlled and supervised exercise training. In CON, the training intervention increased whole body insulin action by 26% and insulin-stimulated leg glucose uptake by 53%, together with increased insulin-stimulated leg blood flow and a more oxidative muscle fiber type distribution. In PCOS, no such changes were found, despite similar training intensity and improvements in VO2max. In skeletal muscle of CON but not PCOS, training increased GLUT4 and HKII mRNA and protein expressions. These data suggest that the impaired increase in whole-body insulin action in women with PCOS with training is caused by an impaired ability to upregulate key glucose-handling proteins for insulin-stimulated glucose uptake in skeletal muscle and insulin-stimulated leg blood flow. Still, other important benefits of exercise training appeared in women with PCOS, including an improvement of the hyperandrogenic state.
U2 - 10.2337/db20-0062
DO - 10.2337/db20-0062
M3 - Journal article
C2 - 32873590
VL - 69
SP - 2267
EP - 2280
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 11
ER -