Metabolomics for enhanced clinical understanding of inflammatory bowel disease

Theresa Louise Boye, Alexander Hammerhøj, Ole Haagen Nielsen, Yulan Wang

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Abstract

Metabolomics is an emerging field involving the systematic identification and quantification of numerous metabolites in biological samples. Precision medicine applies multiomics systems biology to individual patients for reliable diagnostic classification, disease monitoring, and treatment. Multiomics systems biology encompasses genomics, transcriptomics, proteomics, epigenomics, and metabolomics. Therefore, metabolomic techniques could be highly valuable for future clinical decision-making. This review provides a technical overview of two commonly used techniques for metabolomics measurements: mass spectrometry (MS) and proton nuclear magnetic resonance (1H NMR) spectroscopy. We also discuss recent clinical advances in these techniques. Individuals with inflammatory bowel disease (IBD) exhibit significant variability in prognosis and response to treatment. Since both genetic predisposition and environmental factors contribute to this condition, targeting the metabolome may provide key insights for distinguishing and profiling patients with different clinical needs. Additionally, the considerable overlap in the clinical presentation of various disease subtypes emphasizes the need for enhanced diagnostic methods to improve patient care.

Original languageEnglish
Article number123238
JournalLife Sciences
Volume359
Number of pages14
ISSN0024-3205
DOIs
Publication statusPublished - 2024
Externally publishedYes

Bibliographical note

Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

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