Abstract
The glucose-lowering drug metformin has been shown to inhibit complex I of the mitochondrial electron transport chain in skeletal muscle. To investigate this effect in vivo we studied skeletal muscle mitochondrial respiratory capacity and content from patients with type 2 diabetes treated with metformin (n = 14) or sulfonylurea (n = 8) and healthy control (n = 18) participants.
Original language | English |
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Journal | Diabetologia |
Volume | 55 |
Issue number | 2 |
Pages (from-to) | 443-9 |
Number of pages | 7 |
ISSN | 0012-186X |
DOIs | |
Publication status | Published - 2012 |
Keywords
- Blood Glucose
- Body Mass Index
- Case-Control Studies
- Cell Respiration
- Citrate (si)-Synthase
- Diabetes Mellitus, Type 2
- Electron Transport Complex I
- Hemoglobin A, Glycosylated
- Humans
- Hypoglycemic Agents
- Insulin
- Male
- Metformin
- Middle Aged
- Models, Biological
- Muscle, Skeletal
- Oxygen Consumption
- Sulfonylurea Compounds