Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration

Steen Larsen, R Rabøl, C N Hansen, S Madsbad, J W Helge, F Dela

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70 Citations (Scopus)

Abstract

The glucose-lowering drug metformin has been shown to inhibit complex I of the mitochondrial electron transport chain in skeletal muscle. To investigate this effect in vivo we studied skeletal muscle mitochondrial respiratory capacity and content from patients with type 2 diabetes treated with metformin (n = 14) or sulfonylurea (n = 8) and healthy control (n = 18) participants.
Original languageEnglish
JournalDiabetologia
Volume55
Issue number2
Pages (from-to)443-9
Number of pages7
ISSN0012-186X
DOIs
Publication statusPublished - 2012

Keywords

  • Blood Glucose
  • Body Mass Index
  • Case-Control Studies
  • Cell Respiration
  • Citrate (si)-Synthase
  • Diabetes Mellitus, Type 2
  • Electron Transport Complex I
  • Hemoglobin A, Glycosylated
  • Humans
  • Hypoglycemic Agents
  • Insulin
  • Male
  • Metformin
  • Middle Aged
  • Models, Biological
  • Muscle, Skeletal
  • Oxygen Consumption
  • Sulfonylurea Compounds

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