Abstract
Reloaded matrix: Facile optical encoding of polyethylene glycol (PEC) based resins provides a direct identification of compounds in combinatorial libraries, and the structures may be correlated with bioactivity. The new technique, microparticle matrix (MPM) encoding (see picture), circumvents some problems often encountered in solid-phase combinatorial chemistry and is extremely simple to implement. (Figure Presented).
Original language | English |
---|---|
Journal | Angewandte Chemie - International Edition |
Volume | 49 |
Issue number | 20 |
Pages (from-to) | 3473-3476 |
Number of pages | 4 |
ISSN | 1433-7851 |
DOIs | |
Publication status | Published - 3 May 2010 |
Externally published | Yes |
Keywords
- Automated screening
- Combinatorial chemistry
- Encoding
- Fluorescent tags
- Peptides