microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer

Stephanie Geisler Crone; Anders Jacobsen; Birgitte Federspiel; Linda Bardram; Anders Krogh; Anders H. Lund; Lennart Friis-Hansen

doi:10.1186/1476-4598-11-71

microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer

Stephanie Geisler Crone, Anders Jacobsen, Birgitte Federspiel, Linda Bardram, Anders Krogh, Anders H. Lund, Lennart Friis-Hansen

Computational and RNA Biology

Research output: Contribution to journal › Journal article › Research › peer-review

95 Citations (Scopus)

3514 Downloads (Pure)

Abstract

Gastric cancer is the second most common cause of cancer-related death in the world. Inflammatory signals originating from gastric cancer cells are important for recruiting inflammatory cells and regulation of metastasis of gastric cancer. Several microRNAs (miRNA) have been shown to be involved in development and progression of gastric cancer. miRNA-146a (miR-146a) is a modulator of inflammatory signals, but little is known about its importance in gastric cancer. We therefore wanted to identify targets of miR-146a in gastric cancer and examine its biological roles.

Original language	English
Journal	Molecular Cancer
Volume	11
Issue number	71
Pages (from-to)	71
Number of pages	31
ISSN	1476-4598
DOIs	https://doi.org/10.1186/1476-4598-11-71
Publication status	Published - 2012

Keywords

Animals
CARD Signaling Adaptor Proteins
Cell Line, Tumor
Cytokines
Disease Models, Animal
Enzyme Activation
Gene Expression Regulation, Neoplastic
Humans
Mice
Mice, Knockout
MicroRNAs
Monocytes
NF-kappa B
Proteins
Receptors, G-Protein-Coupled
Signal Transduction
Stomach Neoplasms

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10.1186/1476-4598-11-71

microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-kappaB by targeting CARD10 and COPS8 in gastric cancerFinal published version, 2.59 MB

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microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer. / Crone, Stephanie Geisler; Jacobsen, Anders; Federspiel, Birgitte; Bardram, Linda; Krogh, Anders ; Lund, Anders H.; Friis-Hansen, Lennart.

In: Molecular Cancer, Vol. 11, No. 71, 2012, p. 71.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Gastric cancer is the second most common cause of cancer-related death in the world. Inflammatory signals originating from gastric cancer cells are important for recruiting inflammatory cells and regulation of metastasis of gastric cancer. Several microRNAs (miRNA) have been shown to be involved in development and progression of gastric cancer. miRNA-146a (miR-146a) is a modulator of inflammatory signals, but little is known about its importance in gastric cancer. We therefore wanted to identify targets of miR-146a in gastric cancer and examine its biological roles.",

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AU - Crone, Stephanie Geisler

AU - Jacobsen, Anders

AU - Federspiel, Birgitte

AU - Bardram, Linda

AU - Krogh, Anders

AU - Lund, Anders H.

AU - Friis-Hansen, Lennart

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AB - Gastric cancer is the second most common cause of cancer-related death in the world. Inflammatory signals originating from gastric cancer cells are important for recruiting inflammatory cells and regulation of metastasis of gastric cancer. Several microRNAs (miRNA) have been shown to be involved in development and progression of gastric cancer. miRNA-146a (miR-146a) is a modulator of inflammatory signals, but little is known about its importance in gastric cancer. We therefore wanted to identify targets of miR-146a in gastric cancer and examine its biological roles.

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KW - Disease Models, Animal

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KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Mice

KW - Mice, Knockout

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KW - Monocytes

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KW - Proteins

KW - Receptors, G-Protein-Coupled

KW - Signal Transduction

KW - Stomach Neoplasms

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DO - 10.1186/1476-4598-11-71

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