Midlife Forgetfulness and Risk of Dementia in Old Age: Results from the Danish Working Environment Cohort Study

Kazi Ishtiak-Ahmed; Åse Marie Hansen; Erik Lykke Mortensen; Anne Helene Garde; Matias Brødsgaard Grynderup; Finn Gyntelberg; Sabrina Islamoska; Rikke Lund; Thien Kieu Thi Phung; Eva Prescott; Gunhild Waldemar; Kirsten Nabe-Nielsen

doi:10.1159/000500184

Midlife Forgetfulness and Risk of Dementia in Old Age: Results from the Danish Working Environment Cohort Study

Kazi Ishtiak-Ahmed, Åse Marie Hansen, Erik Lykke Mortensen, Anne Helene Garde, Matias Brødsgaard Grynderup, Finn Gyntelberg, Sabrina Islamoska, Rikke Lund, Thien Kieu Thi Phung, Eva Prescott, Gunhild Waldemar, Kirsten Nabe-Nielsen

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Abstract

BACKGROUND: Despite the current evidence of a high prevalence of forgetfulness in middle-aged individuals, and the evidence of a link between midlife memory complaints and biological changes in the brain, no previous study has yet investigated midlife forgetfulness in relation to risk of dementia in old age.

AIMS: We investigated whether midlife forgetfulness was an indicator of an increased risk of dementia in old age.

METHODS: We used data from 3,136 employed men and women who participated in the Danish Work Environment Cohort Study in 1990. These data were linked to Danish national registers. Participants were asked whether their closest relative had ever told them that they were forgetful. Incidence rate ratios (IRR) were estimated using Poisson regression analysis.

RESULTS: At baseline, 749 (24%) study participants were categorized as forgetful, and 86 (2.7%) participants were diagnosed with dementia during a total of 31,724 person-years at risk. After adjusting for sociodemographic factors, comorbidities, and work-related factors, midlife forgetfulness was associated with a higher risk of dementia (IRR = 1.82; 95% CI: 1.12-2.97).

CONCLUSIONS: This study is the first to investigate midlife forgetfulness and dementia, and the results suggest that midlife forgetfulness is an early indicator of an increased risk of dementia in old age.

Original language	English
Journal	Dementia and Geriatric Cognitive Disorders
Volume	47
Issue number	4-6
Pages (from-to)	264-273
Number of pages	10
ISSN	1420-8008
DOIs	https://doi.org/10.1159/000500184
Publication status	Published - 2019

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10.1159/000500184

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Ishtiak-Ahmed, K., Hansen, Å. M., Mortensen, E. L., Garde, A. H., Brødsgaard Grynderup, M., Gyntelberg, F., Islamoska, S., Lund, R., Phung, T. K. T., Prescott, E., Waldemar, G., & Nabe-Nielsen, K. (2019). Midlife Forgetfulness and Risk of Dementia in Old Age: Results from the Danish Working Environment Cohort Study. Dementia and Geriatric Cognitive Disorders, 47(4-6), 264-273. https://doi.org/10.1159/000500184

Midlife Forgetfulness and Risk of Dementia in Old Age : Results from the Danish Working Environment Cohort Study. / Ishtiak-Ahmed, Kazi; Hansen, Åse Marie ; Mortensen, Erik Lykke ; Garde, Anne Helene; Brødsgaard Grynderup, Matias; Gyntelberg, Finn; Islamoska, Sabrina; Lund, Rikke; Phung, Thien Kieu Thi; Prescott, Eva ; Waldemar, Gunhild ; Nabe-Nielsen, Kirsten.

In: Dementia and Geriatric Cognitive Disorders, Vol. 47, No. 4-6, 2019, p. 264-273.

Research output: Contribution to journal › Journal article › Research › peer-review

Ishtiak-Ahmed, K, Hansen, ÅM , Mortensen, EL , Garde, AH, Brødsgaard Grynderup, M, Gyntelberg, F, Islamoska, S, Lund, R, Phung, TKT, Prescott, E , Waldemar, G & Nabe-Nielsen, K 2019, 'Midlife Forgetfulness and Risk of Dementia in Old Age: Results from the Danish Working Environment Cohort Study', Dementia and Geriatric Cognitive Disorders, vol. 47, no. 4-6, pp. 264-273. https://doi.org/10.1159/000500184

Ishtiak-Ahmed, Kazi ; Hansen, Åse Marie ; Mortensen, Erik Lykke ; Garde, Anne Helene ; Brødsgaard Grynderup, Matias ; Gyntelberg, Finn ; Islamoska, Sabrina ; Lund, Rikke ; Phung, Thien Kieu Thi ; Prescott, Eva ; Waldemar, Gunhild ; Nabe-Nielsen, Kirsten. / Midlife Forgetfulness and Risk of Dementia in Old Age : Results from the Danish Working Environment Cohort Study. In: Dementia and Geriatric Cognitive Disorders. 2019 ; Vol. 47, No. 4-6. pp. 264-273.

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abstract = "BACKGROUND: Despite the current evidence of a high prevalence of forgetfulness in middle-aged individuals, and the evidence of a link between midlife memory complaints and biological changes in the brain, no previous study has yet investigated midlife forgetfulness in relation to risk of dementia in old age.AIMS: We investigated whether midlife forgetfulness was an indicator of an increased risk of dementia in old age.METHODS: We used data from 3,136 employed men and women who participated in the Danish Work Environment Cohort Study in 1990. These data were linked to Danish national registers. Participants were asked whether their closest relative had ever told them that they were forgetful. Incidence rate ratios (IRR) were estimated using Poisson regression analysis.RESULTS: At baseline, 749 (24%) study participants were categorized as forgetful, and 86 (2.7%) participants were diagnosed with dementia during a total of 31,724 person-years at risk. After adjusting for sociodemographic factors, comorbidities, and work-related factors, midlife forgetfulness was associated with a higher risk of dementia (IRR = 1.82; 95% CI: 1.12-2.97).CONCLUSIONS: This study is the first to investigate midlife forgetfulness and dementia, and the results suggest that midlife forgetfulness is an early indicator of an increased risk of dementia in old age.",

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AU - Ishtiak-Ahmed, Kazi

AU - Hansen, Åse Marie

AU - Mortensen, Erik Lykke

AU - Garde, Anne Helene

AU - Brødsgaard Grynderup, Matias

AU - Gyntelberg, Finn

AU - Islamoska, Sabrina

AU - Lund, Rikke

AU - Phung, Thien Kieu Thi

AU - Prescott, Eva

AU - Waldemar, Gunhild

AU - Nabe-Nielsen, Kirsten

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N2 - BACKGROUND: Despite the current evidence of a high prevalence of forgetfulness in middle-aged individuals, and the evidence of a link between midlife memory complaints and biological changes in the brain, no previous study has yet investigated midlife forgetfulness in relation to risk of dementia in old age.AIMS: We investigated whether midlife forgetfulness was an indicator of an increased risk of dementia in old age.METHODS: We used data from 3,136 employed men and women who participated in the Danish Work Environment Cohort Study in 1990. These data were linked to Danish national registers. Participants were asked whether their closest relative had ever told them that they were forgetful. Incidence rate ratios (IRR) were estimated using Poisson regression analysis.RESULTS: At baseline, 749 (24%) study participants were categorized as forgetful, and 86 (2.7%) participants were diagnosed with dementia during a total of 31,724 person-years at risk. After adjusting for sociodemographic factors, comorbidities, and work-related factors, midlife forgetfulness was associated with a higher risk of dementia (IRR = 1.82; 95% CI: 1.12-2.97).CONCLUSIONS: This study is the first to investigate midlife forgetfulness and dementia, and the results suggest that midlife forgetfulness is an early indicator of an increased risk of dementia in old age.

AB - BACKGROUND: Despite the current evidence of a high prevalence of forgetfulness in middle-aged individuals, and the evidence of a link between midlife memory complaints and biological changes in the brain, no previous study has yet investigated midlife forgetfulness in relation to risk of dementia in old age.AIMS: We investigated whether midlife forgetfulness was an indicator of an increased risk of dementia in old age.METHODS: We used data from 3,136 employed men and women who participated in the Danish Work Environment Cohort Study in 1990. These data were linked to Danish national registers. Participants were asked whether their closest relative had ever told them that they were forgetful. Incidence rate ratios (IRR) were estimated using Poisson regression analysis.RESULTS: At baseline, 749 (24%) study participants were categorized as forgetful, and 86 (2.7%) participants were diagnosed with dementia during a total of 31,724 person-years at risk. After adjusting for sociodemographic factors, comorbidities, and work-related factors, midlife forgetfulness was associated with a higher risk of dementia (IRR = 1.82; 95% CI: 1.12-2.97).CONCLUSIONS: This study is the first to investigate midlife forgetfulness and dementia, and the results suggest that midlife forgetfulness is an early indicator of an increased risk of dementia in old age.

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