Mind the gap

Sven Larsen-Ledet; Amelie Stein

doi:10.1016/j.str.2023.05.005

Mind the gap

Sven Larsen-Ledet, Amelie Stein^*

^*Corresponding author for this work

Computational and RNA Biology

Research output: Contribution to journal › Comment/debate › Research › peer-review

1 Citation (Scopus)

Abstract

Amino acid deletions are high-risk, high-reward mutations, yet structural consequences are poorly understood. In this issue of Structure, Woods et al. (2023) individually deleted 65 residues from a small α-helical protein, structurally assayed the 17 soluble variants, and developed a computational model of deletion solubility combining Rosetta and AlphaFold2.

Original language	English
Journal	Structure
Volume	31
Issue number	6
Pages (from-to)	641-643
Number of pages	3
ISSN	0969-2126
DOIs	https://doi.org/10.1016/j.str.2023.05.005
Publication status	Published - 2023

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Ltd

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10.1016/j.str.2023.05.005

Cite this

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title = "Mind the gap",

abstract = "Amino acid deletions are high-risk, high-reward mutations, yet structural consequences are poorly understood. In this issue of Structure, Woods et al. (2023) individually deleted 65 residues from a small α-helical protein, structurally assayed the 17 soluble variants, and developed a computational model of deletion solubility combining Rosetta and AlphaFold2.",

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AU - Larsen-Ledet, Sven

AU - Stein, Amelie

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AB - Amino acid deletions are high-risk, high-reward mutations, yet structural consequences are poorly understood. In this issue of Structure, Woods et al. (2023) individually deleted 65 residues from a small α-helical protein, structurally assayed the 17 soluble variants, and developed a computational model of deletion solubility combining Rosetta and AlphaFold2.

U2 - 10.1016/j.str.2023.05.005

DO - 10.1016/j.str.2023.05.005

M3 - Comment/debate

C2 - 37267922

AN - SCOPUS:85159802332

VL - 31

SP - 641

EP - 643

JO - Structure

JF - Structure

SN - 0969-2126

IS - 6

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