Molluscicidal saponins from a Zimbabwean strain of Phytolacca dodecandra

S. T. Thiilborg, S. B. Christensen, Claus Cornett, C. E. Olsen, E. Lemmich

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    Abstract

    Three new monodesmosidic saponins, all glycosides of 2 beta-hydroxyoleanolic acid, were isolated from an aqueous extract of a Zimbabwean strain of Phytolacca dodecandra. Their structures were, mainly by spectroscopic methods (LSIMS, H-1 NMR, COSY, NOESY, TOCSY, J-resolved (1)HNMR, (13)CNMR, HETCOR), established as 3-O-[2',4'-di-O-(beta-D-glucopyranosyl)-beta-D-glucopyranosyl]2 beta-hydroxyoleanolic acid, 3-OO-alpha-L-rhamnopyranosyl-(1-->2)-O-[beta-D-galactopyranosyl- (1-->3)]-beta-D-glucopyranosyl 2 beta-hydroxyoleanolic acid and 3-O-[3'-O-(beta-D-galactopyranosyl)-beta-D-glucopyranosyl] 2 beta-hydroxyoleanolic acid. Two of the saponins were submitted to a preliminary screening for molluscicidal activity against the schistosomiasis transmitting snail Biomphalaria glabrata and showed, respectively, strong and weak activity. In addition, four saponins previously reported from other strains of Phytolacca dodecandra were identified.
    Original languageUndefined/Unknown
    JournalPhytochemistry
    Volume36
    Issue number3
    Pages (from-to)753-759
    Number of pages7
    ISSN0031-9422
    Publication statusPublished - 1994

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