Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging

Katharina H. Clitherow; Craig Murdoch; Sebastian Guy Spain; Anna Mette Handler; Helen E. Colley; Mai Bay Stie; Hanne Morck Nielsen; Christian Janfelt; Paul V. Hatton; Jette Jacobsen

doi:10.1021/acs.molpharmaceut.9b00535

Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging

Katharina H. Clitherow, Craig Murdoch, Sebastian Guy Spain, Anna Mette Handler, Helen E. Colley, Mai Bay Stie, Hanne Morck Nielsen, Christian Janfelt, Paul V. Hatton, Jette Jacobsen

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

201 Downloads (Pure)

Original language	English
Journal	Molecular Pharmaceutics
Volume	16
Issue number	9
Pages (from-to)	3948-3956
ISSN	1543-8384
DOIs	https://doi.org/10.1021/acs.molpharmaceut.9b00535
Publication status	Published - Sep 2019

Keywords

electrospinning
lidocaine
oral mucosa
ex vivo tissue permeation
MALDI-mass spectrometry imaging
drug distribution in tissue

Access to Document

10.1021/acs.molpharmaceut.9b00535Licence: CC BY

acs.molpharmaceut.9b00535Final published version, 5.74 MBLicence: CC BY

Cite this

Clitherow, K. H., Murdoch, C., Spain, S. G., Handler, A. M., Colley, H. E., Stie, M. B., Nielsen, H. M., Janfelt, C., Hatton, P. V., & Jacobsen, J. (2019). Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging. Molecular Pharmaceutics, 16(9), 3948-3956. https://doi.org/10.1021/acs.molpharmaceut.9b00535

Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging. / Clitherow, Katharina H.; Murdoch, Craig; Spain, Sebastian Guy; Handler, Anna Mette; Colley, Helen E.; Stie, Mai Bay ; Nielsen, Hanne Morck ; Janfelt, Christian; Hatton, Paul V.; Jacobsen, Jette.

In: Molecular Pharmaceutics, Vol. 16, No. 9, 09.2019, p. 3948-3956.

Research output: Contribution to journal › Journal article › Research › peer-review

Clitherow, KH, Murdoch, C, Spain, SG, Handler, AM, Colley, HE, Stie, MB , Nielsen, HM , Janfelt, C, Hatton, PV & Jacobsen, J 2019, 'Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging', Molecular Pharmaceutics, vol. 16, no. 9, pp. 3948-3956. https://doi.org/10.1021/acs.molpharmaceut.9b00535

Clitherow, Katharina H. ; Murdoch, Craig ; Spain, Sebastian Guy ; Handler, Anna Mette ; Colley, Helen E. ; Stie, Mai Bay ; Nielsen, Hanne Morck ; Janfelt, Christian ; Hatton, Paul V. ; Jacobsen, Jette. / Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging. In: Molecular Pharmaceutics. 2019 ; Vol. 16, No. 9. pp. 3948-3956.

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